慢性阻塞性肺疾病与空气污染相关性研究进展  

Progress in researches on correlation between chronic obstructive pulmonary disease and air pollution

作　　者：孔德慧 范中杰 KONG De-hui;FAN Zhong-jie(Department of Cardiology,Peking Union Medical College Hospital,Peking Union Medical College,Beijing 100730,China)

机构地区：[1]北京协和医学院北京协和医院心内科,北京100730

出　　处：《中国公共卫生》2021年第9期1438-1442,共5页Chinese Journal of Public Health

基　　金：环保部公益性行业科研专项经费(201509062)。

摘　　要：空气颗粒污染物(PM10、PM2.5)的短期暴露与慢性阻塞性肺部疾病(COPD)发病、加重或死亡的风险相关,但空气气态污染物(CO、NO2、SO2、O3)与COPD相关性的研究尚未得出一致结论。关于空气颗粒污染物长期暴露与COPD相关性的研究仍很匮乏。本文针对空气污染物与COPD相关性的研究进展进行综述,分析气候、人群特征、人文地理因素对空气污染致COPD效应的影响,评估不同污染物与COPD发病、急性加重、死亡的相关程度,旨在为未来的COPD研究方向和防控策略提供依据。Recent studies have shown a significant relationship between ambient particulate matter(particulate matter less than 10 or 2.5 μm in aerodynamic diameter) and the onset, aggravation or death of chronic obstructive pulmonary disease(COPD), but the studies on the correlation between air gaseous pollutants(carbon monoxide, nitrogen dioxide, sulfur dioxide,ozone) and COPD did not reach a consistent conclusion. There was a few studies on the association between chronic exposure and COPD. This paper reviews the latest researches on the correlation between air pollutants and COPD, analyzes the influence of climate, population characteristics and human geography factors on the effect of air pollution on COPD, and aims to evaluate the degree of correlation between different pollutants and the incidence, acute exacerbation and death of COPD, and discuss the future research direction and prevention and control strategies.

关 键 词：慢性阻塞性肺部疾病(COPD) 空气污染 急性和慢性效应 致病机理 流行病学 

分 类 号：R563.9[医药卫生—呼吸系统] R122.26[医药卫生—内科学]