窖蛋白-1在衰老中的作用和信号通路  

Role and signaling pathway of Caveolin-1 in aging

作　　者：侯丽雅 李欣悦 白琳 HOU Liya;LI Xinyue;BAI Lin(NHC Key Laboratory of Human Disease Comparative Medicine,Institute of Laboratory Animal Science,CAMS&PUMC,Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Beijing 100021,China)

机构地区：[1]国家卫生健康委员会人类疾病比较医学重点实验室,中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,北京市人类重大疾病实验动物模型工程技术研究中心,北京100021

出　　处：《中国实验动物学报》2021年第5期675-680,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然基金面上项目(31672374);北京自然基金面上项目(5202024)。

摘　　要：衰老是生物随着时间的推移而自发的必然过程,并会导致与衰老相关的疾病发展,老年疾病的增加使得社会医疗负担加重,因此寻找衰老相关疾病的治疗靶点是衰老生物学重要的研究方向。窖蛋白-1(Caveolin-1,Cav-1)是胞膜窖的重要结构蛋白,参与细胞信号转导、胆固醇平衡、迁移和衰老等许多过程。众多研究表明,Cav-1在介导和调节衰老中发挥重要的功能,本文总结分析了Cav-1在细胞衰老、机体衰老和不同物种衰老中的作用,同时对Cav-1调节衰老的p53/p21、生长因子受体、ROS、K-RAS等上下游分子作了综述,可能为衰老及衰老相关疾病提供潜在的治疗靶点。Aging is an inevitable process in organisms that proceeds spontaneously over time and leads to the development of aging-related diseases.The increase of senile diseases adds to the medical burden of society.Therefore,an important research direction in aging biology is to find therapeutic targets for aging-related diseases.Caveolin-1(Cav-1)is an important structural protein of caveolin,which is involved in many cellular processes,such as signaling transduction,cholesterol balance,migration and aging.Numerous studies have shown that Cav-1 plays an important role in mediating and regulating aging.This article reviews the role and signaling pathways of Cav-1 in aging and potential therapeutic targets for aging and aging-related diseases.

关 键 词：窖蛋白-1 衰老 信号通路 

分 类 号：Q95-33[生物学—动物学]