中国小型猪在生物医药领域的研究进展  

Progress in the use of Chinese miniature pigs in biomedical research

作　　者：陈雨荣 安星兰 张胜[1] 翟岩辉 于浩[2] 代相鹏 李子义[1] CHEN Yurong;AN Xinglan;ZHANG Sheng;ZHAI Yanhui;YU Hao;DAI Xiangpeng;LI Ziyi(National&Local Joint Engineering Laboratory for Animal Models of Human Diseases,First Hospital,Jilin University,Changchun 130021,China;College of Animal Science,Jilin University,Changchun 130062)

机构地区：[1]吉林大学第一医院人类疾病动物模型国家地方联合工程实验室,长春130021 [2]吉林大学动物科学学院,长春130062

出　　处：《中国实验动物学报》2021年第5期695-706,共12页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家重点研发计划(干细胞及转化研究重点专项)(2017YFA0104400);吉林大学第一医院启动经费(04035020001)。

摘　　要：小型猪在生理、解剖结构、营养代谢、药物代谢以及疾病发生发展上与人类相似,被广泛应用于人类疾病研究中。我国小型猪资源丰富,不同种群遗传性状稳定并各具特色。但如何结合中国小型猪的特点,建立符合生物医药研究需要的人类疾病小型猪模型仍处于探索阶段。本文对不同品种中国小型猪在人类疾病模型研究中的应用现状进行概述,以期为进一步利用中国小型猪研究人类疾病提供参考和指导。Miniature pigs are similar to humans in terms of their physiology,anatomy,nutrition,metabolism,drug metabolism,and disease development and are therefore widely used in the study of human disease. Chinese miniature pigs have stable genetics but are also outbred. However,the harnessing of the characteristics of Chinese miniature pigs in the establishment of mini-pig models of human disease that meet the needs of biomedical research is still in the exploratory stage. In this article,we summarize the status of the breeds of Chinese miniature pig with respect to research into human diseases in order to provide a reference and guidance for the further use of this species in the study of human diseases.

关 键 词：中国小型猪 生物医药 疾病模型 

分 类 号：Q95-33[生物学—动物学]