同型半胱氨酸和血管性假性血友病因子联合检测在深静脉血栓中的临床应用  

Clinical Application of Homocysteine and Von Willebrand Factor in patients with deep vein thrombosis

作　　者：刘礼青 卢晓荷 张春来[1] 秦榛[1] LIU Li-qing;LU Xiao-he;ZHANG Chun-lai(Department of Clinical Labortory,the Affiliated Hospital of Shandong Universitey of Traditional Chinese Medical,Shandong Jinan 250011)

机构地区：[1]山东中医药大学附属医院检验科,山东济南250011

出　　处：《医学检验与临床》2021年第10期1-3,7,共4页Medical Laboratory Science and Clinics

基　　金：山东省医药卫生科技发展计划项目(2019WS584)。

摘　　要：目的:探讨同型半胱氨酸(homocysteine,Hcy)浓度、血管性假性血友病因子(von Willebrand Factor,vWF)抗原活性联合检测在下肢深静脉血栓(deep venous thrombosis,DVT)诊断中的应用价值。方法:检测42例DVT患者溶栓前后Hcy浓度、vWF抗原活性的变化,选取同期健康体检者42例纳入对照组,检测两项指标并进行比较。结果:研究组治疗前、后Hcy浓度分别为(36.6±27.1)μmol/L、(32.0±18.5)μmol/L,均高于对照组的(10±3.8)μmol/L;vWF抗原活性(265.1±80.3)%、(232.4±55.9)%,均高于对照组的(107.4±31.6)%,差异均有统计学意义(P<0.05)。而治疗后Hcy浓度(32.0±18.5)μmol/L与治疗前(36.6±27.1)μmol/L比较无统计学意义(P>0.05),治疗后vWF抗原活性(232.4±55.9)%与治疗前(265.1±80.3)%比较有统计学意义(P<0.05)。结论:血清Hcy浓度和血浆vWF抗原活性在DVT患者血液中明显升高,两者联合检测对DVT的诊断中有较好的应用价值,且创伤小、费用低廉、操作简单、检测速度快,应在临床诊断中大力推广和应用。Objective:To investigate the application value of homocysteine(Hcy)concentration and von Willebrand Factor(VWF)antigen activity detection in patients with deep venous thrombosis(DVT).Methods:Hcy concentration and vWF antigen activity in 42 DVT patients before and after thrombolysis treatment were detected.At the same time,42 healthy people during the same period were selected as the control group,and the two indicators were tested and compared with the patients with DVT.Results:The concentration of Hcy in the study group before and after treatment were(36.6±27.1)μmol/L and(32.0±18.5)μmol/L respectively,which were higher than those in the control group(10±3.8μmol/L);The vWF antigen activity was(265.1±80.3)%and(232.4±55.9)%respectively,which were higher than that in the control group[(107.4±31.6)%](P<0.05).The Hcy concentration(32.0±18.5μmol/L)after treatment was not statistically significant compared with that(36.6±27.1μmol/L)before treatment(P>0.05).However,the vWF antigen activity(232.4±55.9)%after treatment was lower than that[(265.1±80.3)%]before treatment(P<0.05).Conclusion:Serum Hcy concentration and plasma vWF antigen activity are significantly increased in patients with DVT.The combined detection of the two indicators has a good application value in the diagnosis of DVT.This detection method has the advantages of small trauma,low cost,simple operation and fast detection speed,and should be widely promoted and applied in clinical diagnosis.

关 键 词：下肢深静脉血栓 同型半胱氨酸 血管性假性血友病因子抗原 诊断 

分 类 号：R54[医药卫生—心血管疾病]