多肿瘤抑制基因、细胞增殖标志指数及表皮生长因子受体与宫颈鳞状上皮内病变患者分级的相关性  

Correlation between multiple tumor suppressor genes,cell proliferation marker index and epidermal growth factor receptor and the grading of patients with cervical squamous intraepithelial lesions

作　　者：钟辉[1] 化金金 曹颖[2] 龙璐雯 ZHONG Hui;HUA Jinjin;CAO Ying;LONG Luwen(Department of Pathology,Huaibei Maternal and Child Health Hospital,Huaibei,Anhui 235000,China;Department of Ultrasound,Huaibei Maternal and Child Health Hospital,Huaibei,Anhui 235000,China)

机构地区：[1]淮北市妇幼保健院病理科,安徽淮北235000 [2]淮北市妇幼保健院超声科,安徽淮北235000

出　　处：《中国性科学》2021年第10期55-59,共5页Chinese Journal of Human Sexuality

基　　金：淮北市科技计划项目(2020HK16)。

摘　　要：目的观察多肿瘤抑制基因(p63)、细胞增殖标志指数(Ki-67)及表皮生长因子受体(EGFR)与宫颈鳞状上皮内病变(SIL)患者分级的相关性。方法选取2016年1月至2020年12月淮北市妇幼保健院收治的218例宫颈SIL患者作为研究对象。均于确诊时检测p63、Ki-67及EGFR,评估宫颈SIL分级,记录高度宫颈SIL(HSIL)组与低度宫颈SIL(LSIL)组患者的p63、Ki-67、EGFR阳性率及联合检查阳性率,分析p63、Ki-67、EGFR阳性率及联合检查阳性率与宫颈SIL分级的相关性。结果经病理检查结果显示,218例宫颈SIL患者中,有88例宫颈HSIL患者(HSIL组),有130例宫颈LSIL患者(LSIL组);宫颈HSIL组p63、Ki-67、EGFR总阳性率及联合检查总阳性率均高于宫颈LSIL组,差异具有统计学意义(P<0.05);经Ken-dall′tau-b相关性分析显示,宫颈SIL患者p63、Ki-67及EGFR阳性率均与宫颈SIL分级呈正相关(P<0.05)。结论宫颈SIL患者p63、Ki-67、EGFR阳性率及联合检查阳性率高均可反馈HSIL风险,可将p63、Ki-67、EGFR阳性率作为宫颈SIL分级评估的辅助手段,指导临床评估患者预后风险。Objective To observe the correlation between multiple tumor suppressor genes(p63),cell proliferation marker index(Ki-67),epidermal growth factor receptor(EGFR)and the grading of patients with cer-vical squamous intraepithelial lesion(SIL).Methods 218 patients with cervical SIL admitted to Huaibei Maternal and Child Health Hospital from January 2016 to December 2020 were selected.p63,Ki-67 and EGFR were detected at the time of diagnosis,cervical SIL grade was evaluated,and the positive rates of p63,Ki-67 and EGFR and com-bined test were recorded in the high cervical SIL(HSIL)group and the low cervical SIL(LSIL)group.The corre-lation between the positive rate of p63,Ki-67,EGFR and cervical SIL grade was analyzed.Results Pathological examination showed that among 218 patients with cervical SIL,88 patients with cervical HSIL(HSIL group)and 130 patients with cervical LSIL(LSIL group).The total positive rates of p63,Ki-67,EGFR and combined exami-nation in HSIL group were higher than those in LSIL group(P<0.05).Kendall′tau-b correlation analysis showed that positive rates of p63,Ki-67 and EGFR were positively correlated with cervical SIL grade(P<0.05).Conclusions The high positive rates of p63,Ki-67,EGFR and joint examination in patients with cervical SIL can feed back the risk of HSIL,the positive rates of p63,Ki-67 and EGFR can be used as auxiliary means for cervical SIL grading evaluation to guide clinical evaluation of prognostic risk of patients.

关 键 词：宫颈鳞状上皮内病变 多肿瘤抑制基因 细胞增殖标志指数 血流动力学 人乳头瘤病毒 

分 类 号：R711[医药卫生—妇产科学]