基于低剂量CT图像的双胞胎个体化可计算模型构建  

Construction of patient-specific computational twins model based on low dose CT images

作　　者：曲水音 卓维海[1] 谢添武 Qu Shuiyin;Zhuo Weihai;Xie Tianwu(Institute of Radiation Medicine,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学放射医学研究所,上海200032

出　　处：《中华放射医学与防护杂志》2021年第10期765-771,共7页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的为了弥补胎儿辐射剂量学研究中双胞胎数字化模型的空白,本研究拟基于临床低剂量CT图像构建双胞胎可计算体模。方法采用阈值自动分割和手动分割结合的方式对孕妇患者的低剂量CT图像进行分割与标识,在3D建模软件中对分割后的母体轮廓、胎儿轮廓和骨骼等组织器官进行三维重建与曲面重构,再进一步依据国际放射防护委员会(ICRP)89号报告和世界卫生组织(WHO)报告中胎儿发育数据构建胎儿内部器官。结果建立了全球第一套基于低剂量CT图像的个体化双胞胎非均匀有理B样条(NURBS)曲面模型,该模型的外部轮廓、骨骼,在母体的大小、位置和姿势均与真实患者完全一致。每个所构建的胎儿模型具有25个器官/组织,并且其质量与参考值的相对偏差<10%。结论本研究构建了一套基于低剂量CT图像的个性化双胞胎可计算体模,填补了双胞胎可计算模型的空白,有助于更加准确评估怀有双胞胎的孕妇患者在接受放射诊断的过程中胎儿接受的电离辐射剂量。Objective In order to make up for the gap in the digital model of twins in the study of fetal radiation dosimetry,this study intends to construct a computational twins phantom based on low-dose CT images.Methods The low-dose CT images of a pregnant patient were segmented by the combination of threshold automatic segmentation and manual segmentation,which were derived into stereolithography files.The maternal contour,fetal contour and bone structure were constructed using 3D modeling software,and the organ mass was adjusted according to the reference values of ICRP Publication 89 and WHO report after the organs were scaled on a specific scale.Results The first set of Non-Uniform Rational B-Splines(NURBS)surface phantom of twins in China was established.The external contours,bones,size,position and posture of the phantom were completely consistent with those of the real human body.Each fetus had 25 organs or tissues.After optimization and adjustment,the relative deviation between the twin phantom and the reference value of organ mass was less than 10%.Conclusions In this study,a personalized computational phantom of twins based on low-dose CT images is constructed,which fills the gap in the twin model.It is helpful in estimating the dose by the fetus from ionizing radiation received in the process of radiation diagnosis of pregnant women with twins.

关 键 词：孕妇 双胞胎 可计算模型 非均匀有理B样条曲面 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]