静脉用丙氨酰-谷氨酰胺双肽临床应用专家共识(2021)  

Expert consensus on clinical application of intravenous alanyl-glutamine dipeptide

作　　者：朱明炜[1] 杨桦 陈伟[3] 王新颖 江华[5] 唐云[6] 贾震易[7] 周华[8] 赵彬 陈丽如[10] 康维明[11] Zhu Mingwei;Yang Hua;Chen Wei;Wang Xinying;Jiang Hua;Tang Yun;Jia Zhenyi;Zhou Hua;Zhao bin;Chen Liru;Kang Weiming(Department of General Surgery,Department of Hepato-bilio-pancreatic Surgery,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of General Surgery,the Second Affiliated Hospital,Army Medical University,Chongqing 400037,China;Department of Parenteral and Enteral Nutrition,Peking Union Medical College Hospital,Beijing 100730,China;Department of General Surgery,General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China;Institute for Emergency and Disaster Medicine,Sichuan Provincial People's Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China;Department of General Surgery,First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of General Surgery,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200233,China;Department of Critical Care Medicine,Beijing Tsinghua Changgung Hospital,Beijing 102218,China;Department of Pharmacy,Peking Union Medical College Hospital,Beijing 100730,China;Department of Nutrition,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of General Surgery,Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]北京医院,普通外科,肝胆胰外科,国家老年医学中心,中国医学科学院老年医学研究院,100730 [2]陆军军医大学第二附属医院普通外科,重庆400037 [3]中国医学科学院,北京协和医学院,北京协和医院临床营养科,100730 [4]东部战区总医院普通外科,南京210002 [5]电子科技大学附属医院,四川省人民医院急诊医学与灾难医学研究所,成都610072 [6]解放军总医院第一医学中心普外科,北京100036 [7]上海交通大学第六人民医院普外科,200233 [8]清华大学附属长庚医院危重症医学科,北京102218 [9]中国医学科学院,北京协和医学院,北京协和医院药剂科,100730 [10]北京医院营养科,100730 [11]中国医学科学院,北京协和医学院,北京协和医院基本外科,100730

出　　处：《中华临床营养杂志》2021年第4期193-200,共8页Chinese Journal of Clinical Nutrition

摘　　要：丙氨酰-谷氨酰胺双肽是肠外营养的重要组分,进入体内可分解为丙氨酸和谷氨酰胺,具有维护肠屏障、改善免疫、促进蛋白质合成、调控炎性介质的产生和释放等功能。大量临床证据显示,其有较好的有效性和安全性,合理应用可减少术后并发症、缩短住院时间、节省医疗费用。临床实践中发现,丙氨酰-谷氨酰胺双肽在适用人群、使用剂量等多方面国内外尚存在不同意见。中华医学会肠外肠内营养学分会组织国内相关学科专家,遵循最新指南和共识编写国际标准,形成该专家共识,以期达到“规范应用、患者收益”的目标。Alanyl-glutamine dipeptide is an important component in parenteral nutrition,which can be decomposed into alanine and L-glutamine in vivo.It plays multiple functions including maintaining intestinal barrier,improving immunity,promoting protein synthesis,and regulating the production and release of inflammatory mediators.Substantial clinical evidences have demonstrated its favorable effectiveness and safety.Rational application of alanyl-glutamine dipeptide can reduce postoperative complications,shorten hospital stay and save medical costs.There are still controversies at home and abroad on the applicable population and dosage of alanyl-glutamine dipeptide.Chinese Society of Parenteral and Enteral Nutrition organized China's experts of related disciplines to compile international standards in accordance with the latest guidelines and consensus,so as to achieve the goal of standardized application and patient benefits.

关 键 词：谷氨酰胺 丙氨酰-谷氨酰胺双肽 肠屏障功能 感染并发症 

分 类 号：R969[医药卫生—药理学]