A群C群流脑多糖疫苗纳入扩大免疫规划对流脑发病率影响的中断时间序列分析  

Interrupted time series analysis for impacts of the inclusion of group A and C meningococcal polysaccharide vaccine in the Expanded Program on Immunization on the incidence of meningococcal meningitis

作　　者：王燕[1] 付荣华[1] 顾松义[1] 段亚彤[1] 方兴[1] WANG Yan;FU Rong-hua;GU Song-yi;DUAN Ya-tong;FANG Xing(Liaoning Provincial Center for Disease Control and Prevention,Shenyang 110005,China)

机构地区：[1]辽宁省疾病预防控制中心,辽宁沈阳110005

出　　处：《公共卫生与预防医学》2021年第6期12-15,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的评价A群C群流脑多糖疫苗纳入扩大免疫规划对流脑发病率影响。方法收集辽宁省1995—2019年流脑发病率,利用中断时间序列分析方法定量分析流脑发病水平和变化趋势。结果A群C群流脑多糖疫苗纳入扩大免疫规划前,辽宁省流脑年均报告发病率为0.3442/10万,发病率呈下降趋势,平均每年下降0.0319/10万;纳入扩大免疫规划后,年均报告发病率为0.0151/10万,呈下降趋势,平均每年下降0.0042/10万。结论A群C群流脑多糖疫苗纳入扩大免疫规划后,辽宁省流脑年发病水平降低,并对流脑发病趋势下降产生长期持续的作用。Objective To evaluate the impact of the inclusion of(MPSV-AC)vaccine in the Expanded Program on Immunization(EPI)on the incidence of meningococcal meningitis.Methods Data on the incidence of meningococcal meningitis in Liaoning from 1995 to 2019 were collected,Interrupted time series(ITS)analysis was used to assess the level and slope change of the incidence of meningococcal meningitis before and after the inclusion of MPSV-AC vaccine in the EPI.Results Before the MPSV-AC vaccine was included in the EPI,the average annual incidence rate of meningococcal meningitis was 0.3442/100000,the incidence rate showed a descending trend with an annual decrement of 0.0319/100000.After the MPSV-AC vaccine was included in the EPI,the average annual incidence rate of meningococcal meningitis was 0.0151/100000 and the incidence of meningococcal meningitis showed a descending trend with an annual decrement of 0.0042/100000.Conclusion The incidence of meningococcal meningitis reduced after the inclusion of MPSV-AC vaccine in EPI,and the EPI strategy had a continuous effect on the decreasing trend of meningococcal meningitis incidence.

关 键 词：流行性脑脊髓膜炎 疫苗 中断时间序列 

分 类 号：R186[医药卫生—流行病学]