高血压患者颈动脉内中膜厚度与心踝血管指数的相关性  

Correlation between carotid intima-media thickness and cardio-ankle vascular index in hypertension subjects

作　　者：黄薇 王宏宇[1,2] 刘金波 刘欢[1,2] 赵红薇 赵娜[1,2] Huang Wei;Wang Hongyu;Liu Jinbo;Liu Huan;Zhao Hongwei;Zhao Na(Department of Vascular Medicine,Peking University Shougang Hospital,Beijing 100144,China;Vascular Health Research Center,Peking University Health Science Center,Beijing 100144,China)

机构地区：[1]北京大学首钢医院血管医学中心,北京100144 [2]北京大学医学部血管健康研究中心,北京100144

出　　处：《中华临床医师杂志（电子版）》2021年第7期481-484,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：北京市卫生局首都卫生发展科研专项(首发2011-4026-02);北京大学首钢医院院内基金(2010-Y002,2012Y04)。

摘　　要：目的探讨高血压患者颈动脉内中膜厚度(CIMT)与心踝血管指数(CAVI)之间的相关性。方法选择2012年1月至12月在北京大学首钢医院血管医学中心健康体检的324人,根据血压水平分为对照组(173例)及高血压组(151例)。应用超声及动脉僵硬度自动检测装置测定CIMT及CAVI。结果高血压组冠心病、卒中发病率显著高于对照组(P<0.05);高血压组患者CIMT、CAVI水平明显高于对照组[(0.62±0.23)mm vs(0.51±0.22)mm;8.40±1.51 vs 7.46±1.10,P均<0.001]。高血压患者CIMT与CAVI呈显著正相关性(r=0.191,P<0.05)。多元线性回归分析提示,年龄、收缩压在高血压患者中与CIMT独立相关(β=0.253,P=0.004;β=0.283,P=0.001)。结论高血压患者CIMT显著高于非高血压人群,与CAVI呈正相关性,提示CIMT在预警动脉硬化中发挥重要作用。Objective To investigate the correlation between carotid intima-media thickness(CIMT)and cardio-ankle vascular index(CAVI)in hypertension subjects.Methods A total of 324 subjects in Department of Vascular Medicine,Peking University Shougang Hospital were enrolled into our study,and they were divided into two groups based on blood pressure levels:control group(173 cases)and hypertension group(151 cases).Two-dimensional ultrasound and VS-1000 were used to measure CIMT and CAVI.Results The prevalence of coronary artery disease and stroke was significantly higher in the hypertension group than in the control group(P<0.05).The levels of CIMT and CAVI were significantly higher in the hypertension group than in the control group[(0.62±0.23)mm vs(0.51±0.22)mm and 8.40±1.51 vs 7.46±1.10,respectively,P<0.001].There was a positive correlation between CIMT and CAVI in hypertension subjects(r=0.191,P<0.05).Multivariate analysis showed that age and systolic blood pressure were independent risk factors for CIMT in hypertension subjects(β=0.253,P=0.004;β=0.283,P=0.001).Conclusion CIMT is significantly higher and positively correlated with CAVI in hypertension subjects,indicating the role of CIMT in predicting arteriosclerosis.

关 键 词：颈动脉内中膜厚度 心踝血管指数 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]