吗啉硝唑氯化钠注射液对胆囊结石合并胆总管结石患者术后细菌感染的杀菌效果  

Bactericidal Effect of Morinidazole Sodium Chloride Injection on Postoperative Bacterial Infection in Patients with Cholecystolithiasis Complicated with Common Bile Duct Stones

作　　者：瞿胜[1] QU Sheng(The First People's Hospital of Jiujiang,Jiujiang Jiangxi 332000,China)

机构地区：[1]九江市第一人民医院,江西九江332000

出　　处：《药品评价》2021年第18期1124-1127,共4页Drug Evaluation

摘　　要：目的:分析吗啉硝唑氯化钠注射液对胆囊结石合并胆总管结石患者术后细菌感染的杀菌效果。方法:选择2019年12月至2020年12月期间九江市第一人民医院收治的70例胆囊结石合并胆总管结石的术后细菌感染患者作为研究对象,根据入院时间将其分成对照组(35例)与观察组(35例),两组的入院时间分别为2019年12月至2020年5月、2020年6月至2020年12月。两组均已接受相应的手术治疗,手术后对照组采用奥硝唑氯化钠注射液常规抗感染药物治疗,观察组采用吗啉硝唑氯化钠注射液治疗,对比两组的杀菌效果、治疗前后感染指标[白细胞计数(WBC)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、中性粒细胞百分比(N%)]、不良反应发生情况(胃轻度不适、困倦眩晕、四肢麻木、皮疹瘙痒)。结果:观察组与对照组的细菌完全清除率分别为91.43%、71.43%,观察组高于对照组(P<0.05);治疗后,观察组的WBC、ALT、AST分别为(6.12±1.05)×10^(9)/L、(39.68±3.57)U/L、(37.63±3.22)U/L,均低于对照组的(10.96±1.87)×10^(9)/L、(51.23±4.26)U/L、(49.37±3.58)U/L,观察组的N%为(63.22±4.25)%,高于对照组的(56.14±4.01)%(P<0.05);观察组与对照组的不良反应总发生率分别为5.72%、22.85%,观察组低于对照组(P<0.05)。结论:对胆囊结石合并胆总管结石术后细菌感染患者,采用吗啉硝唑氯化钠注射液治疗抗感染、杀菌效果良好,安全性高。Objective:To analyze the bactericidal effect of morinidazole sodium chloride injection on postoperative bacterial infection in patients with cholecystolithiasis complicated with common bile duct stones.Methods:70 patients with postoperative bacterial infection of cholecystolithiasis complicated with choledocholithiasis admitted to The First People’s Hospital of Jiujiang from December 2019 to December 2020 were selected as the research objects,and divided into control group(35 cases)and observation group(35 cases)according to the time of admission.The time of admission was from December 2019 to May 2020 and from June 2020 to December 2020,respectively.Both groups have received corresponding surgical treatment.After surgery,the control group was treated with ornidazole and sodium chloride injection,while the observation group was treated with morinidazole and sodium chloride injection.The bactericidal effect,infection indexes before and after treatment[WBC,ALT,AST,neutrophil percentage(N%)],occurrence of adverse reactions(mild discomfort in stomach,drowsiness and dizziness,numbness of limbs,and itching of skin rash)were compared between the two groups.Results:The complete bacterial clearance rate of observation group and control group was 91.43%and 71.43%,respectively,and the observation group was higher than the control group(P<0.05).After treatment,WBC,ALT and AST in the observation group were(6.12±1.05)×10^(9)/L,(39.68±3.57)U/L and(37.63±3.22)U/L,respectively.The N%of the observation group was(63.22±4.25)%,which was higher than that of the control group(56.14±4.01)%(P<0.05).The total incidence of adr in the observation group and the control group was 5.72%and 22.85%,respectively,and the observation group was lower than the control group(P<0.05).Conclusion:The treatment of cholecystolithiasis combined with choledocholithiasis after operation with morinidazole sodium chloride injection has good anti-infection,bactericidal effect and high safety.

关 键 词：胆囊结石合并胆总管结石 吗啉硝唑氯化钠注射液 奥硝唑氯化钠注射液 杀菌效果 不良反应 

分 类 号：R969[医药卫生—药理学]