阿奇霉素联合蓝芩口服液对急性细菌性上呼吸道感染小儿血清炎症因子及症状消失的影响  

Effects of Azithromycin Combined with Lanqin Oral Liquid on the Disappearance of Serum Inflammatory Factors and Symptoms in Children with Acute Bacterial Upper Respiratory Tract Infection

作　　者：肖爱 戴峥嵘 王旅兰 XIAO Ai;DAI Zhengrong;WANG Lvlan(Third People's Hospital of Jingdezhen City,Jingdezhen Jiangxi 333000,China)

机构地区：[1]景德镇市第三人民医院,江西景德镇333000

出　　处：《药品评价》2021年第18期1135-1137,共3页Drug Evaluation

摘　　要：目的:探讨注射用阿奇霉素联合蓝芩口服液在小儿急性细菌性上呼吸道感染中的应用价值。方法:选择2018年1月至2020年12月景德镇市第三人民医院收治的急性细菌性上呼吸道感染患儿80例,按随机数字表法分为两组,各40例。对照组采用阿奇霉素治疗,研究组采用阿奇霉素+蓝芩口服液,两组均持续用药5~7 d。比较两组血清炎症因子水平、症状消失时间、临床疗效及不良反应。结果:治疗前,两组白细胞计数(WBC)、C反应蛋白(CRP)比较,差异无统计学意义(P>0.05);治疗后,研究组WBC、CRP低于对照组,差异有统计学意义(P<0.05);研究组发热、咳痰、流脓涕、咽部充血消失时间短于对照组,治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组不良反应相当,差异无统计学意义(P>0.05)。结论:阿奇霉素联合蓝芩口服液能够有效降低急性细菌性上呼吸道感染患儿机体血清炎症因子水平,促进临床症状消失,且不会增加不良反应。Objective:To explore the application value of azithromycin for injection combined with Lanqin oral liquid in children with acute bacterial upper respiratory tract infection.Methods:A total of 80 children with acute upper bacterial respiratory infection admitted to Third People’s Hospital of Jingdezhen City from January 2018 to December 2020 were selected and divided into two groups according to the random number table method,with 40 cases in each group.The control group was treated with azithromycin,and the study group was treated with azithromycin+Lanqin oral liquid.Both groups were treated for 5-7 days.The levels of serum inflammatory factors,the time of symptom disappearance,clinical efficacy and adverse reactions were compared between the two groups.Results:Before treatment,the white blood cell count(WBC)and C-reactive protein(CRP)of the two groups were not statistically different(P>0.05);after treatment,the WBC and CRP of the study group were lower than those of the control group,and the difference was statistically significant(P<0.05);the disappearance time of fever,sputum,purulent nose,and pharyngeal congestion in the study group was shorter than that in the control group,and the total effective rate of treatment was higher than that in the control group,the difference was statistically significant(P<0.05);the adverse reactions in the two groups were comparable,and the difference was not statistically significant(P>0.05).Conclusion:Azithromycin combined with Lanqin oral liquid can effectively reduce the level of serum inflammatory factors in children with acute bacterial upper respiratory tract infection,promote the disappearance of clinical symptoms,and will not increase adverse reactions.

关 键 词：呼吸道感染 细菌感染 阿奇霉素 蓝芩口服液 炎症因子 儿童 学龄前 

分 类 号：R725.6[医药卫生—儿科]