噻托溴铵粉雾剂治疗慢性阻塞性肺气肿的临床疗效  

Clinical efficacy of tiotropium bromide powder spray in the treatment of chronic obstructive emphysema

作　　者：朱莎莎 周宁[1] 丁宁[1] 任晓月 周敏[1] ZHU Shasha;ZHOU Ning;DING Ning(Xuzhou First People's Hospital,Xuzhou 221000,China)

机构地区：[1]江苏省徐州市第一人民医院,221000

出　　处：《临床合理用药杂志》2021年第30期4-7,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨噻托溴铵粉雾剂治疗慢性阻塞性肺气肿的临床疗效。方法选取徐州市第一人民医院2018年1月—2021年1月收治的慢性阻塞性肺气肿患者80例,随机分为对照组与试验组,每组40例。对照组予以布地奈德联合复方异丙托溴铵雾化治疗,试验组在对照组基础上联合噻托溴铵粉雾剂治疗。比较2组临床疗效,治疗前后第1秒用力呼吸容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC、最大通气量(MVV)、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、6 min步行距离,并观察2组不良反应发生情况。结果试验组治疗有效率高于对照组(P<0.05)。治疗前2组FEV_(1)、FVC、FEV_(1)/FVC、MVV、PaCO_(2)、PaO_(2)、6 min步行距离比较,差异无统计学意义(P>0.05);治疗后组FEV_(1)、FVC、FEV_(1)/FVC、MVV、PaO_(2)高于对照组,PaCO_(2)低于对照组,6 min步行距离长于对照组(P<0.05)。试验组不良反应发生率低于对照组(P<0.05)。结论噻托溴铵粉雾剂治疗慢性阻塞性肺气肿的临床疗效确切,可有效改善临床症状、肺功能及血气指标,且安全性较高。Objective To discuss the clinical efficacy of tiotropium bromide powder spray in the treatment of chronic obstructive emphysema.Methods A total of 80 cases of patients with chronic obstructive emphysema were selected from January 2018 to January 2021 in Xuzhou First People’s Hospital,which were randomly divided into control group and experimental group,with 40 cases in each group.The control group was treated with budesonide combined with compound ipratropium bromide,the experimental group was treated with tiotropium bromide powder spray on the basis of the control group.Clinical efficacy,forced breathing volume in the first second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC,maximum ventilation volume(MVV),arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),6 min walking distance were compared between the two groups,and the incidence of adverse reactions were observed.Results The effective rate of the experimental group was higher than that of the control group(P<0.05).There was no significant difference in FEV_(1),FVC,FEV_(1)/FVC,MVV,PaCO_(2),PaO_(2) and 6 min walking distance between the two groups before treatment(P>0.05);after treatment,the experimental group of FEV_(1),FVC,FEV_(1)/FVC,MVV and PaO_(2) were higher than those in the control group,PaCO_(2) was lower than control group,and the 6 min walking distance was longer than control group(P<0.05).The incidence of adverse reactions in the experimental group was lower than that in the control group(P<0.05).Conclusion Tiotropium bromide powder spray have an exact clinical effect for chronic obstructive emphysema,which can effectively improve clinical symptoms,pulmonary function and blood gas indexes,and with high safety.

关 键 词：慢性阻塞性肺气肿 噻托溴铵粉雾剂 治疗结果 不良反应 

分 类 号：R563.3[医药卫生—呼吸系统]