特利加压素治疗感染性休克的临床疗效  

Clinical effect of terlipressin in septic shock

作　　者：周正宇[1] 徐平平 段玉波 刘碧霞[1] 刘鹏 吕赛平[1] ZHOU Zhengyu;XU Pingping;DUAN Yubo(Department of Critical Care Medicine,Jiangxi Cancer Hospital,Nanchang 330029,China)

机构地区：[1]江西省肿瘤医院重症医学科,江西省南昌市330029

出　　处：《临床合理用药杂志》2021年第30期26-28,31,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：江西省卫生计生委科技计划(20195431)。

摘　　要：目的探讨特利加压素治疗感染性休克的临床疗效。方法选取江西省肿瘤医院2019年12月—2020年12月收治的感染性休克患者60例,随机分为对照组和观察组,各30例。对照组患者采用常规治疗,观察组患者在对照组的基础上静脉泵入特利加压素治疗。比较2组患者治疗前及治疗1周后平均动脉压(MAP)、外周循环阻力指数(SVRI)、尿量、尿素氮(BUN)、血肌酐(Scr)、去甲肾上腺素用量,病死率及治疗期间不良反应发生情况、呼吸机使用时间、ICU入住时间。结果治疗前2组患者MAP、SVRI、尿量、BUN、Scr、去甲肾上腺素用量比较,差异无统计学意义(P>0.05);治疗后观察组患者MAP、SVRI高于对照组,尿量多于对照组,BUN、Scr、去甲肾上腺素用量低于对照组(P<0.05)。仅对照组1例因腹腔大出血死亡,其他患者均存活28 d以上。观察组不良反应发生率低于对照组(P<0.05)。观察组患者呼吸机使用时间、ICU入住时间短于对照组(P<0.05)。结论采用特利加压素治疗感染性休克患者可有效改善肾功能及血压,减少去甲肾上腺素用量,缩短治疗时间,降低病死率。Objective To study the clinical effect of terlipressin in septic shock.Methods A total of 60 cases of patients with septic shock were selected from December 2019 to December 2020 in Jiangxi Cancer Hospital,which were randomly divided into the control group and the observation group,30 cases in each group.Patients in the control group were given conventional treatment,while patients in the observation group were given terlipressin on the basis of control group.MAP,SVRI,urine volume,BUN,Scr,dosage of norepinephrine before treatment and 1 week after treatment,mortality rate,incidence of adverse reactions during treatment,ventilator use time,ICU stay time were compared between the two groups.Results Before treatment,there was no significant difference of MAP,SVRI,urine volume,BUN,Scr,dosage of norepinephrine before treatment between the two groups(P>0.05);1 week after treatment,MAP,SVRI in the observation group were higher than those in the control group,urine volume was more than that in the control group,BUN,Scr,dosage of norepinephrine were lower than those in the control group(P<0.05).Only one patient in the control group died of abdominal hemorrhage,and all the other patients survived for more than 28 days.Incidence of adverse reactions during treatment in the observation group was lower than that in the control group(P<0.05).Ventilator use time,ICU stay time in the observation group were shorter than those in the control group(P<0.05).Conclusion The treatment of septic shock patients with terlipressin can effectively improve renal function and blood pressure,reduce the dosage of norepinephrine,shorten the treatment time and reduce the mortality rate.

关 键 词：感染性休克 特利加压素 治疗结果 

分 类 号：R459.7[医药卫生—急诊医学]