泼尼松联合低分子肝素治疗小儿肾病综合征的效果及对APTT和PT的影响  

Effect of prednisone combined with low molecular weight heparin in the treatment of children with nephrotic syndrome and its influence on APTT and PT

作　　者：王晶晶[1] 崔晴晴[1] 张延蕊[1] 谢庆芝[1] WANG Jingjing;CUI Qingqing;ZHANG Yanrui(Affiliated Hospital of Binzhou Medical College,Shandong Province,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院,山东省滨州市256603

出　　处：《临床合理用药杂志》2021年第32期19-21,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察泼尼松联合低分子肝素治疗小儿肾病综合征的效果及对活化部分凝血活酶时间(APTT)和凝血酶原时间(PT)的影响。方法选取2017年10月-2019年10月滨州医学院附属医院收治的肾病综合征患儿140例,采用随机数字表法分为观察组和对照组,每组70例。观察组采用泼尼松联合低分子肝素治疗,对照组采用泼尼松治疗。比较2组临床疗效、治疗前后单项症状积分、APTT、PT及不良反应。结果治疗4周后,观察组总有效率为97.14%,高于对照组的81.43%(χ^(2)=9.035,P=0.003)。治疗4周后,2组单项症状积分均低于治疗前,且观察组低于对照组(P<0.01)。治疗4周后,2组APTT、PT均较治疗前延长(P<0.01),但2组间比较差异无统计学意义(P>0.05)。2组不良反应总发生率比较差异无统计学意义(χ^(2)=0.431,P=0.512)。结论泼尼松联合低分子肝素治疗小儿肾病综合征可有效提高临床效果,改善患儿的临床症状及凝血功能,且不良反应发生率较低。Objective To explore the clinical effect of prednisone combined with low molecular weight heparin in the treatment of children with nephrotic syndrome and its influence on the levels of Actirated partial thromboplastin time(APTT)and prothrombin time(PT).Methods A total of 140 children with nephrotic syndrome admitted to the Affiliated Hospital of Binzhou Medical College from October 2017 to October 2019 were selected and divided into observation group and control group by random number table method,with 70 cases in each group.The observation group was treated with prednisone combined with low molecular weight heparin,and the control group was treated with prednisone.The clinical efficacy,individual symptom scores,APTT,PT before and after treatment,and adverse reactions were compared between the two groups.Results After 4 weeks of treatment,the total effective rate of the observation group was 97.14%,which was higher than 81.43%of the control group(χ^(2)=9.035,P=0.003).After 4 weeks of treatment,the individual symptom scores of the two groups were lower than before treatment,and the observation group was lower than the control group(P<0.01).After 4 weeks of treatment,the APTT and PT of the two groups were longer than before treatment(P<0.01),but the difference between the two groups were not statistically significant(P>0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(χ^(2)=0.431,P=0.512).Conclusion Prednisone combined with low molecular weight heparin in the treatment of pediatric nephrotic syndrome can effectively improve the clinical effect,improve the clinical symptoms and coagulation function of children,and the incidence of adverse reactions is low.

关 键 词：肾病综合征 小儿 泼尼松 低分子肝素 临床疗效 活化部分凝血活酶时间 凝血酶原时间 

分 类 号：R726.9[医药卫生—儿科]