搭载大米发酵滤液的透明质酸可溶解性微针的保湿抗皱效果研究  

Hyaluronic acid dissolving microneedle patch loaded with rice fermentation filtrate for improved moisturizing and anti-wrinkle effects

作　　者：杨帆 周正 郭苗 周雅捷 张金龙 周紫燕 YANG Fan;ZHOU Zheng;GUO Miao;ZHOU Ya-jie;ZHANG Jin-long;ZHOU Zi-yan(Mageline Biology Tech Co.,Ltd.,Wuhan,Hubei 430070,China;Tianshiwei Biotechnology Co.,Ltd.,Wuhan,Hubei 430070,China)

机构地区：[1]麦吉丽生物科技有限公司,湖北武汉430070 [2]武汉天时维生物科技有限公司,湖北武汉430070

出　　处：《日用化学品科学》2021年第11期42-46,共5页Detergent & Cosmetics

摘　　要：采用激光烧蚀和微成型工艺制作了一款搭载大米发酵滤液的透明质酸可溶性微针,通过细胞实验验证微针的体外生物安全性,水分含量测试和经皮失水测试TWEL验证其保湿功效;通过VISIA观测人体使用效果实验,验证其安全和抗皱功效;研究了微针贴片的特性、溶解进度和透皮深度对其功效的影响。结果表明,搭载大米发酵滤液的透明质酸可溶性微针具有良好的生物相容性、皮肤渗透性,保湿和抗皱功效,且使用中不引起副作用和不适感。The hyaluronic acid dissolving microneedle patches loaded with rice fermentation filtrate were made by a laser-ablation and micro-molding process.The in-vitro biological safety of the microneedle was verified by cell experiment.Its moisturizing effect was verified by moisture content test and transepidermal water loss test(TWEL).Its safety and anti-wrinkle effect were verified by human experiment observed by VISIA.The characteristics,dissolution progress and transdermal depth of microneedle patches were studied.The results show that the hyaluronic acid dissolving microneedles loaded with rice fermentation filtrate have good biocompatibility,skin permeability,moisturizing and anti-wrinkle effects,and do not cause side effects or discomfort.

关 键 词：可溶解性微针 透明质酸 经皮吸收 保湿抗皱 大米发酵提取物 

分 类 号：TQ658[化学工程—精细化工]