“双心疾病”气滞血瘀心胆郁热证患者的证候特点及证候程度与炎性因子、负性情绪量表的相关性研究  

Study on the relationship between syndrome characteristics degree and inflammatory factor and negative emotional scale in"double heart disease"patients with Qi stagnation blood stasis and heart gallbladder heat stagnation

作　　者：马迪[1,2] 陈婧 叶超 赵海滨[4] MA Di;CHEN Jing;YE Chao;ZHAO Hai‑bin(Beijing University of Chinese Medicine,Beijing 100029,China;The Third Affiliated Hospital of Beijing University of TCM,Beijing 100029,China;Dongzhimen Hospital of Beijing University of TCM,Beijing 100700,China;Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学第三附属医院,北京100029 [3]北京中医药大学东直门医院,北京100700 [4]北京中医药大学东方医院,北京100078

出　　处：《海南医学院学报》2021年第21期1613-1617,共5页Journal of Hainan Medical University

基　　金：北京中医药大学基本科研业务费专项基金资助项目(2019-JYB-JS-174);北京市科学技术委员会“首都特色临床应用研究”项目(Z161100000516136)。

摘　　要：目的:探讨“双心疾病”气滞血瘀心胆郁热证患者超敏C‑反应蛋白(Hs‑CRP)、总胆固醇(TC)、甘油三酯(TG)、负性情绪量表与中医证候评分的相关性。方法:选择52例西医诊断为双心疾病,中医证候辨识为气滞血瘀心胆郁热证的患者,应用酶联免疫吸附法检测Hs‑CRP、TC、TG水平,应用中医证候量表评分量化中医证候,匹兹堡睡眠质量指数量表评分(PSQI)量化睡眠程度,症状自评量表焦虑分量表评分(SCL‑90)量化焦虑程度,分析中医证候评分与Hs‑CRP、TC、TG水平、匹兹堡睡眠质量指数量表、症状自评量表焦虑分量表的相关性。结果:血清超敏C‑反应蛋白水平、血清甘油三酯水平与中医证候评分呈显著正相关(P<0.05);总血清胆固醇水平与中医证候评分呈正相关,但未见显著性差异(P>0.05);中医证候评分与PSQI评分、SCL‑90焦虑评分呈显著正相关(P<0.05)。结论:双心疾病气滞血瘀心胆郁热证患者在炎症因子水平、血脂水平和负性情绪评分方面具有其特征性的证候特点;上述指标的水平可以在一定程度上反映中医证候的严重程度,为该病的中医药治疗提供依据。Objective:To discuss the correlation between hypersensitivity C‑reactive Protein(Hs‑CRP),total cholesterol(TC),triglyceride(TG),negative emotion scale and TCM syndrome scores in"Double Heart Disease"patients with Qi stagnation blood stasis and heart gallbladder heat stagnation.Methods:Fifty‑two patients in western medicine diagnosis of double heart disease,in TCM syndrome identified as Qi stagnation blood stasis heart gallbladder heat stagnation syndrome was selected to,detect it Hs‑CRP,TC,TG levels by ELISA,use TCM Syndromes scale to evaluate TCM syndrome,use the Pittsburgh Sleep Quality Index(PSQI)and self‑rating symptom scale(SCL‑90)to assess anxiety and sleep levels,analyze the correlation between TCM syndrome scores and Hs‑CRP,TC,TG level,PSQI index,SCL‑90 index.Results:There was a significant positive correlation between Hs‑CRP,TG level and TCM syndrome scores(P<0.05);TC level was postively correlated with TCM syndrome scores,but there was no statistical significance(P>0.05);There was a significant positive correlation between PSQI index,SCL‑90 index and TCM syndrome scores(P<0.05).Conclusion:In"Double Heart Disease"patients with Qi stagnation blood stasis and heart gallbladder heat stagnation,there are characteristic syndrome changes in terms of inflammatory factor level,blood lipid level and negative emotion score;the above indexes can reflect the severity of TCM syndromes to a certain extent and provide the basis for the effective intervention treatment of TCM.

关 键 词：双心疾病 气滞血瘀心胆郁热证 证候 负性情绪量表 超敏C‑反应蛋白 

分 类 号：R259[医药卫生—中西医结合]