实验动物遗传质量监测技术研究进展与应用  

Research Progress and Application of Genetic Quality Detection Technology in Laboratory Animal

作　　者：杜小燕[1] 霍学云[1] 陈振文[1] DU Xiaoyan;HUO Xueyun;CHEN Zhenwen(School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学基础医学院,北京100069

出　　处：《实验动物科学》2021年第4期1-5,共5页Laboratory Animal Science

基　　金：国家科重点研发计划(No.2017YFD0501602);北京市科学技术项目(D18110000518002)。

摘　　要：遗传质量监测是实验动物质量控制的重要内容之一,也是发现实验动物遗传变异及保障动物质量符合要求的重要手段。随着科学技术发展,尤其是生物科学的不断进步,实验动物遗传质量监测技术也从形态学遗传标记发展到DNA分子水平,越来越趋于准确、简便和快速。本文梳理了实验动物遗传质量监测技术沿革,分析比较了各项技术的优点和局限性,并对其应用前景进行了展望。Genetic quality monitoring is one of the most important composition of laboratory animal quality control.It is essential method to find the genetic variation in laboratory animal and to confirm standardized animal quality.With the development of science and technology,especially with biological science progress,the technique of laboratory animal quality monitoring boosts from morphological genetic markers to DNA molecular level,and become more accurate,convenient and speedy.We sort out the history about methods in laboratory animal quality control,compare and analyze the advantages and limits of these methods,discuss the bright prospect of their application as well.

关 键 词：实验动物 遗传 质量监测 

分 类 号：Q95-33[生物学—动物学]