Wnt信号通路与心脏病理生理学相关研究状况  

Current situation of Wnt signaling pathway and cardiac pathophysiology

作　　者：王海英 李超 孙昊天 张雅文 张雨晴 匡浩然 张冉 苑金香 WANG Hai-ying;LI Chao;SUN Hao-tian;ZHANG Ya-wen;ZHANG Yu-qing;KUANG Hao-ran;ZHANG Ran;YUAN Jin-xiang(Department of Physiology,Jining Medical University,Jining 272067,Shandong Province,China;College of Basic Medicine,Jining Medical University,Jining 272067,Shandong Province,China;Collaborative Innovation Center Scientific Research Department,Jining Medical University,Jining 272067,Shandong Province,China)

机构地区：[1]济宁医学院基础医学院生理学教研室,山东济宁272067 [2]济宁医学院基础医学院,山东济宁272067 [3]济宁医学院科研处协同创新中心,山东济宁272067

出　　处：《中国临床药理学杂志》2021年第20期2847-2849,2860,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金青年基金资助项目(81703490);山东省医药卫生科技发展计划基金资助项目(202002061311);济宁医学院教师科研扶持基金资助项目(JYFC2019KJ013);山东省省级大学生创新训练计划基金资助项目(S201910443021)。

摘　　要：Wnt信号通路是人体中最基本的通路之一,由Wnt配体蛋白、Wnt受体以及其他信号物质组成。它依靠依赖β-catenin的经典途径和非依赖β-catenin的非经典途径在人体中发挥重要作用。经典通路中的β-catenin可以诱导肥大基因的表达。非经典通路中的Wnt-5a/c-Jun-N-末端激酶信号通路会促进炎症反应的发生。本研究详细介绍了Wnt信号通路的具体途径以及Wnt信号通路与心肌梗死、心肌肥大、心力衰竭、动脉粥样硬化、心率失常、心房颤动和心肌纤维化等心脏疾病的关系,为上述心脏疾病的治疗开辟了新的研究方向。Wnt signaling pathway was one of the most basic pathways in the human body,which consisted of Wnt ligand proteins,Wnt receptors and other signaling substances.It played an important role in the human body by relying on both classical and non-classicalβ-catenin-dependent pathways.β-catenin in the classical pathway could induce the expression of hypertrophy gene.The non-classical Wnt-5a/c-Jun N-terminal kinase signaling pathway could aggravate the inflammatory response.In this study,we discussed the relationship between the Wnt signaling pathway and myocardial infarction,myocardial hypertrophy,heart failure,atherosclerosis,arrhythmias,atrial fibrillation,and myocardial fibrosis.It opened up a new research direction for the treatment of these heart diseases.

关 键 词：WNT信号通路 心肌梗死 心肌肥大 心力衰竭 动脉粥样硬化 心率失常 心房颤动 心肌纤维化 

分 类 号：R97[医药卫生—药品]