UPLC-Q-TOF/MS法在毒物检测领域应用研究进展  

Application of ultra performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry in toxicological detection

作　　者：赵森 吴小军[1] 赵鹏 王爱华[1] 任昕昕[1] 常靖[1] 于忠山[1] 郭琳琳[3] 张云峰 Zhao Sen;Wu Xiaojun;Zhao Peng;Wang Aihua;Ren Xinxin;Chang Jing;Yu Zhongshan;Guo Linlin;Zhang Yunfeng(Institute of Forensic Science,Ministry of Public Security,Beijing,100038,China;Zhejiang Police College,Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province,Hangzhou 310053;SCIEX China,Beijing,100015)

机构地区：[1]公安部物证鉴定中心,北京100038 [2]浙江警察学院,浙江省毒品防控技术研究重点实验室,浙江杭州310053 [3]上海爱博才思分析仪器贸易有限公司,北京100015

出　　处：《中国法医学杂志》2021年第5期524-527,共4页Chinese Journal of Forensic Medicine

基　　金：中央级基本科研业务费专项资金(2019JB042)。

摘　　要：超高效液相色谱-串联四极杆飞行时间质谱技术作为一种新的检验、筛查技术,具有检测范围宽、分析速度快、灵敏度高、数据库共享程度高等优点,其在毒物检测领域的应用有必要进行总结概括,拓宽思路。结合近年来UPLC-Q-TOF/MS技术和该技术在毒物检验领域内应用方面的文章,概述了该技术的基本原理,分析了UPLCQ-TOF/MS技术在农药、违禁药物、植物源性毒素等常见毒物检测领域的研究进展和优劣势。对其未来在法庭科学检验鉴定方面的工作进行了总结和展望。该技术自出现以来不断进步,为研究者提供了更好的研究手段,已经越来越多应用于各类型检测领域,同时在法庭科学毒物检验鉴定领域的应用也越来越广泛。Ultra performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry(UPLCQ-TOF/MS) technology, as a new test and screening technology, has the advantages of wide detection range, fast analysis speed, high sensitivity and high database sharing. It is necessary to summarize and expand its application in the field of toxicological detection. According to the UPLC-Q-TOF/MS technology and the literatures about toxicological testing and identification published in recent years, we summarize the basic principles of the technology, and introduce the research advances on application of UPLC-Q-TOF/MS technology in pesticide, illegal drug, plant toxin detection and its advantages and disadvantages. This paper summarizes and discusses the application of UPLC-Q-TOF/MS technology in forensic toxicological detection. UPLC-Q-TOF/MS technology has been improving since its appearance, providing researchers with better research methods. It has been used more and more in various fields, including forensic toxicological detection.

关 键 词：法庭科学 高效液相色谱-串联四极杆飞行时间质谱法 毒物检测 研究进展 

分 类 号：DF795.1[医药卫生—法医学]