MRI纹理分析鉴别眼眶孤立性纤维瘤与神经鞘瘤  

MRI Texture Analysis in Differential Diagnosis of Orbital Solitary Fibrous Tumor and Neurilemmoma

作　　者：张宝月 苏云杉 沙欧 尤梦晶 王蕊[1] 向述天 ZHANG Baoyue;SU Yunshan;SHA Ou(Department of Radiology,Affiliated Hospital of Yunnan University,Kunming,Yunnan Province 650021,P.R.China)

机构地区：[1]云南大学附属医院放射科,昆明650021 [2]昆明医科大学,650500

出　　处：《临床放射学杂志》2021年第10期1869-1873,共5页Journal of Clinical Radiology

基　　金：昆明医科大学2021年研究生创新基金项目(编号:2021S284)。

摘　　要：目的探讨MRI纹理分析(TA)对眼眶孤立性纤维瘤(SFT)与眼眶神经鞘瘤(ON)的鉴别诊断价值。方法回顾性分析经术后病理证实的9例SFT和13例ON患者。使用MaZda软件在MR常规序列轴位图像上勾画感兴趣区(ROI)获得TA结果,计算观察者间及观察者组内相关系数(ICC),应用LASSO算法进行特征降维,得到可以鉴别两种病变的TA特征参数,绘制其受试者工作特征(ROC)曲线评价其对鉴别SFT与ON的诊断效能。结果在平扫T_(1)WI、T_(2)WI、扩散加权成像(DWI)及T_(1)WI轴位增强扫描四个序列分别提取的15个纹理特征参数中,对ICC均>0.75的特征进行LASSO选择,获得第90百分位数、偏度、峰度、Z轴游程不均匀性、Z轴行程比5个特征参数,其中在T_(2)WI序列Z轴行程比鉴别诊断价值较大,曲线下面积(AUC)为0.906,最佳临界值为0.437,敏感度为88.89%,特异度为100%;在DWI序列峰度鉴别诊断价值较大,其AUC为0.786,最佳临界值为-0.207,敏感度为66.67%,特异度为84.62%;在增强T_(1)WI序列偏度鉴别诊断价值较大,AUC为0.896,最佳临界值为-0.253,敏感度为100%,特异度为66.67%。结论常规MR不同序列图像纹理特征参数有助于区分眼眶SFT与ON。Objective To evaluate the diagnostic performance of MRI texture analysis(TA)for differentiation of orbital neurilemmoma(ON)from solitary fibrous tumor(SFT).Methods 9 patients with SFT and 13 patients with ON confirmed by pathology were retrospectively analyzed.Mazda software was used in the conventional MR sequences outline extracting ROI and texture features,Inter-and intra-class correlation coefficients(ICCs)were calculated from two different observers.The Least Absolute Shrinkage and Selection Operator(LASSO)algorithm for characteristic dimensionality reduction were used to analyze the value of TA between the two groups.The ROC curve of the characteristic parameters with statistical significance was drawn,and the AUC was used as the main indicator to evaluate its effect of the diagnosis in distinguishing between ON and SFT.Results Among the 15 characteristic parameters extracted from four sequences of plain T_(1)WI,T_(2)WI,DWI and T_(1)WI axial enhancement,all features with ICCs>0.75 were chosen to further select the LASSO algorithm,5 features including Perc.90%,Skewness,Kurtosis,Z-RLNonUnionand Z-Fraction demonstrated statistically significant differences.There was significant differential diagnostic value of Z-Fraction in T_(2)WI,and AUC was 0.906,the optimal critical value was 0.437,the sensitivity was 88.89%,and the specificity was 100%.On DWI,kurtosis,which had better differential diagnostic value,had the largest AUC:0.786,the best critical value was-0.207,sensitivity was 66.67%,specificity was 84.62%.There was optimaldifferential diagnostic value of skewness in enhanced T_(1)WI,in which AUC was 0.896,the best critical value was-0.253,and the sensitivity and specificity were 100%and 66.67%,respectively.Conclusion TA parameters based on conventional MR sequence images could contribute to discriminate ON from SFT.

关 键 词：眼眶孤立性纤维瘤 眼眶神经鞘瘤 磁共振成像 纹理分析 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.72[医药卫生—诊断学]