预测两型肝包虫病肝切除术后并发症列线图的建立及评价  

Establishment and evaluation of a nomogram for predicting post-hepatectomy complications in two types of hepatic echinococcosis

作　　者：郭兵[1] 庞明泉[1] 许晓磊 韩军伟 王海久[1] GUO Bing;PANG Mingquan;XU Xiaolei;HAN Junwei;WANG Haijiu(Qinghai Province Key Laboratory of Hydatid Disease Research,Department of Hepatopancreatobiliary Surgery,Qinghai University Affiliated Hospital,Xining 810001,China)

机构地区：[1]青海大学附属医院肝胆胰外科,青海省包虫病研究重点实验室,西宁810001

出　　处：《临床肝胆病杂志》2021年第11期2626-2631,共6页Journal of Clinical Hepatology

基　　金：国家重点研发计划项目(2017YFC0909900);青海省科技厅项目(2020-ZJ-Y01);2018年青海省卫生系统指导性计划课题(2018-wjzdx-118)。

摘　　要：目的通过分析两型肝包虫病肝切除术后并发症(PHC)的相关危险因素,建立预测肝包虫病PHC发生风险的列线图,并评价其临床使用价值。方法收集青海大学附属医院2015年1月—2020年8月收治的263例两型肝包虫病行肝切除手术患者的临床资料,并进行回顾性分析,263例患者中PHC组93例,对照组170例。非正态分布的计量资料2组间比较采用Mann-Whitney U秩和检验,正态性计量资料2组间比较采用独立样本t检验;计数资料2组间比较采用χ2检验和Fisher确切概率法。通过单因素和多因素logistic回归筛选出两型肝包虫病PHC的独立危险因素。根据独立危险因素所占权重,构建列线图预测风险模型。采用Bootstrap重采样法进行模型的内部验证、构建受试者工作特征曲线对模型的区分度进行评价、使用校准曲线和Hosmer-Lemeshow检验对模型的一致性进行评价、绘制临床决策曲线分析(DCA)验证模型的临床有效性。结果ALBI评分(OR=3.694,95%CI:1.860~7.336)、手术时间(O R=2.848,95%CI:1.384~5.859)、术中出血量(OR=4.832,95%CI:2.384~9.793)、包虫直径(OR=3.073,95%CI:1.528~6.177)是两型肝包虫发生PHC的独立危险因素(P值均<0.05)。基于上述4个独立危险因素所占权重构建列线图风险预测模型,模型的受试者工作特征曲线下面积为0.877(95%CI:0.831~0.923);Bootstrap重采样法进行内部验证的一致性指数(C-index)为0.871,表明模型的区分度良好。校准曲线观测值和实际值贴合,Hosmer-Lemeshow检验(P=0.905)均显示列线图风险预测模型的预测值与实际观测值一致性良好。当阈概率为35.6%时,DCA显示的临床净获益为22%;在8%~89%阈概率区间内有较好的临床适用性。结论ALBI评分、手术时间、术中出血量、包虫直径是两型肝包虫病患者发生PHC的独立危险因素,以此为基础构建的列线图风险预测模型具有较好的准确度、一致性及临床实用性。Objective To establish a nomogram for predicting the risk of post-hepatectomy complications(PHC)in hepatic echinococcosis by analyzing the risk factors for PHC in two types of hepatic echinococcosis,and to investigate its value in clinical practice.Methods A retrospective analysis was performed for the clinical data of 263 patients with two types of hepatic echinococcosis who underwent hepatectomy in Qinghai University Affiliated Hospital from January 2015 to August 2020,and among these patients,93 were enrolled as PHC group and 170 were enrolled as control group.The Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups,and the independent samples t-test was used for comparison of normally distributed continuous data between two groups;the chi-square test and the Fisher’s exact test were used for comparison of categorical data between two groups.Univariate and multivariate logistic regression analyses were used to screen out independent risk factors for PHC,and a nomogram risk prediction model was established based on the weight of each independent risk factor.The Bootstrap resampling method was used for internal verification of the model;the receiver operating characteristic(ROC)curve was plotted to evaluate the discriminatory ability of the model;calibration curve and the Hosmer-Lemeshow test were used to evaluate the consistency of the model;decision curve analysis(DCA)was performed to verify the clinical effectiveness of the model.Results Albumin-bilirubin(ALBI)score(odds ratio[OR]=3.694,95%confidence interval[CI]:1.860-7.336,P<0.05),time of operation(OR=2.848,95%CI:1.384-5.859,P<0.05),intraoperative blood loss(OR=4.832,95%CI:2.384-9.793,P<0.05),and hydatid diameter(OR=3.073,95%CI:1.528-6.177,P<0.05)were independent risk factors for PHC in two types of hepatic echinococcosis.A nomogram risk prediction model was established based on the weight of the above four independent risk factors,and the model had an area under the ROC curve of 0.877(95%CI:0.831-0.92

关 键 词：棘球蚴病 肝 肝切除术 手术后并发症 危险因素 列线图 

分 类 号：R657.3[医药卫生—外科学] R532.32[医药卫生—临床医学]