低氧诱导因子-1在心血管疾病中的研究进展  

Progress of hypoxiainducible factor-1 in cardiovascular diseases

作　　者：王倩倩[1] 宋双 程艳丽[2] Wang Qianqian;Song Shuang;Cheng Yanli(Binzhou Medical University,Binzhou 256600,China;Department of Cardiology,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院,山东256600 [2]滨州医学院附属医院心血管内科,山东256600

出　　处：《国际医药卫生导报》2021年第22期3592-3594,共3页International Medicine and Health Guidance News

摘　　要：低氧诱导因子-1(hypoxiainducible factor-1,HIF-1)是一种可被低氧调节的异二聚体转录因子。近期研究发现,HIF-1在血管生成、能量调节、细胞凋亡、自噬等方面对心血管疾病的发展起着重要的调控作用。探索HIF-1在心血管疾病中的作用机制,将会为心脏疾病的预防和治疗提供更多有效策略。Hypoxiainducible factor-1(HIF-1)is a heterodimeric transcription factor which can be regulated by hypoxia.Accumulating evidences have shown that HIF-1 plays a significant role in the development of cardiovascular diseases,such as angiogenesis,energy metabolism,apoptosis,and autophagy.Therefore,exploring the mechanism of HIF-1 in cardiovascular diseases will provide more effective strategies for the prevention and treatment of heart disease.

关 键 词：低氧诱导因子-1 心血管疾病 预防 治疗 

分 类 号：R54[医药卫生—心血管疾病]