轮状病毒非结构蛋白4结构与功能的研究进展  

Progress in the structure and function of rotavirus non-structural protein 4

作　　者：阙祥尧 张善锋 王明臣 王鹏[2,3] Que Xiangyao;Zhang Shanfeng;Wang Mingchen;Wang Peng(Department of Biochemistry and Molecular Biology,School of Basic Medical,Zhengzhou University,Zhengzhou 450000,China;Department of Basic Teaching and Research,School of Nursing and Health,Zhengzhou University,Zhengzhou 450000,China;Department of Pharmacology,Zhengzhou Institute of Industrial Application Technology,Zhengzhou 451150,China)

机构地区：[1]郑州大学基础医学院生物化学与分子生物学系,450000 [2]郑州大学护理与健康学院基础教研室,450000 [3]郑州工业应用技术学院药理教研室,451150

出　　处：《中华微生物学和免疫学杂志》2021年第10期817-820,共4页Chinese Journal of Microbiology and Immunology

基　　金：河南省高等学校科技创新人才项目(20HASTI047);河南省科技厅项目(202102310069)。

摘　　要：轮状病毒(rotavirus,RV)是引起5岁以下儿童腹泻病的主要病原体之一,但RV感染性腹泻的发生机制尚不明确。RV基因组编码6个结构蛋白(VP1~VP4、VP6和VP7)和6个非结构蛋白(NSP1~NSP6),其中NSP4可与RV其他非结构蛋白或结构蛋白相互作用产生相应的生物学功能,是RV感染、复制和腹泻机制中的关键因素。本文就目前国内外关于NSP4结构与功能的相关研究进行综述。Rotavirus(RV)is one of the main pathogens causing diarrhea in children under five years old,but the mechanism of RV-infected diarrhea is still unclear.The RV genome encodes six structural proteins(VP1-VP4,VP6 and VP7)and six non-structural proteins(NSP1-NSP6),among which NSP4 can interact with other non-structural proteins or structural proteins of RV to produce corresponding biological functions,and is a key factor in the formation of RV morphology,the process of infection and the pathogenesis of diarrhea.In this paper,the current domestic and foreign studies on the structure and function of NSP4 are reviewed.

关 键 词：轮状病毒 非结构蛋白 NSP4 

分 类 号：R373.2[医药卫生—病原生物学]