金水相生方结合西医常规疗法治疗代谢综合征阴虚热盛证临床研究  

Clinical study of Jinshui-Xiangsheng Decoction combined with conventional western medicine in the treatment of yin deficiency and heat excess syndrome of metabolic syndrome

作　　者：王文艳[1] 陈易 高文澜[1] 李斯斯[1] 张敏[1] 熊必丹[1] 张毅[1] Wang Wenyan;Chen Yi;Gao Wenlan;Li Sisi;Zhang Min;Xiong Bidan;Zhang Yi(Department of Endocrinology,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院内分泌科,200071

出　　处：《国际中医中药杂志》2021年第10期960-964,共5页International Journal of Traditional Chinese Medicine

基　　金：上海市科委,上海市2017年度"科技创新行动计划"临床医学领域项目(17401970300)。

摘　　要：目的评价金水相生方结合西医常规疗法治疗代谢综合征(metabolism syndrome,MS)阴虚热盛证的疗效。方法将符合入选标准的2018年10月-2020年5月上海市中医医院内分泌科MS阴虚热盛证患者60例,按随机数字表法分为2组,每组30例。对照组采用西医规范治疗加生活方式干预,观察组在对照组基础上服用金水相生方。2组均治疗12周。分别于治疗前后进行中医证候评分,采用全自动生化分析仪和增强化学发光免疫分析法检测空腹血糖、TG、TC、HDL-C、LDL-C、空腹胰岛素(FINS),记录患者腰围、BMI、血压水平,评价临床疗效。结果观察组总有效率为93.3%(28/30)、对照组为60.0%(18/30),2组比较差异有统计学意义(χ^(2)=4.135,P=0.016)。观察组治疗后腰围、BMI、收缩压、舒张压均低于对照组(t值分别为4.650、2.687、2.134、2.333,P<0.01或P<0.05),空腹血糖、FINS、TG、TC、LDL-C、HDL-C均低于对照组(t值分别为2.812、2.899、2.678、2.485、2.527、2.905,P值均<0.05)。观察组治疗后中医证候评分[(3.87±2.21)分比(6.50±2.01)分,t=-4.827]低于对照组(P<0.01)。结论金水相生方结合西医常规疗法可有效改善MS阴虚热盛证患者临床症状及代谢紊乱状态。Objective To observe the clinical effect of the Jinshui-Xiangsheng Decoction in treating metabolic syndrome(MS)with yin deficiency and heat.Methods From October 2018 to May 2020,a total of 60 patients with MS and Yin deficiency and heat syndrome in the Department of Endocrinology,Shanghai Hospital of Traditional Chinese Medicine who met the selection criteria were divided into 2 groups according to a random number table,with 30 in each group.The control group took Western medicine standard treatment and lifestyle intervention,and the observation group took Jinshui-Xiangsheng Decoction on the basis of the control group.Both groups were treated for 12 weeks.TCM syndrome scores were performed before and after treatment,and fasting blood glucose,TG,TC,HDL-C,LDL-C,and fasting insulin(FINS)were detected by automatic biochemical analyzer and enhanced chemiluminescence immunoassay.We aimed to observe and record the patient's waist circumference,BMI,blood pressure level,and evaluate the clinical efficacy.Results The total effective rate was 93.3%(28/30)in the observation group and 60.0%(18/30)in the control group.There was significant difference between the two groups(χ^(2)=4.135,P=0.016).After treatment,waist circumference,BMI,systolic blood pressure and diastolic blood pressure in the observation group were significantly lower than those in the control group(t values were 4.650,2.687,2.134 and 2.333,respectively,P<0.01 or P<0.05),and fasting blood glucose,FINS,TG,TC,LDL-C and HDL-C were significantly lower than those in the control group(t values were 2.812,2.899,2.678,2.485,2.527 and 2.905,respectively,all Ps<0.05).The score of TCM syndrome[(3.87±2.21)vs.(6.50±2.01),t=-4.827]in the observation group was significantly lower than that of the control group(P<0.01).Conclusion Combination of conventional western medicine treatment and Jinshui-Xiangsheng Decoction can improve clinical objective indicators and clinical symptom scores,and improve metabolic disorder state for the patients with metabolic syndrome and Yin defi

关 键 词：代谢综合征 阴虚热盛证 金水相生方 中西医结合疗法 

分 类 号：R589[医药卫生—内分泌]