红细胞寿命变异影响糖化血红蛋白水平的研究进展  

Research progress on the effect of red blood cell longevity variation on glycated hemoglobin level

作　　者：周赛君[1] 黄帅 于珮[1] ZHOU Saijun;HUANG Shuai;YU Pei(Blood Purification Center of Zhu Xianyi Memorial Hospital of Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津医科大学朱宪彝纪念医院血液净化中心,300070

出　　处：《中国糖尿病杂志》2021年第10期787-789,共3页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81600743);天津市自然科学基金(17JCYBJC27000);天津市卫生健康委科技项目(ZC20128)。

摘　　要：HbA1c是T2DM诊断和管理的重要指标,是评价T2DM患者血糖管理达标的"金标准",也是临床调整降糖方案的主要依据。HbA1c检测值不仅取决于平均血糖水平,还受红细胞寿命影响。高血糖可引起红细胞寿命缩短,而红细胞寿命变异导致HbA1c检测值偏离真实水平。校正红细胞寿命变异对HbA1c水平的影响是目前临床亟待解决的课题。本文对红细胞寿命变异影响HbA1c水平的研究进展进行综述。HbA1c is an important indicator for diagnosis of type 2 diabetes mellitus(T2DM),the"gold standard"for evaluating the blood glucose management,and the main basis for clinical adjustment of the hypoglycemic program.The detection value of HbA_(1)c depends not only on the average blood glucose level,but also on the life span of red blood cells(RBC).Hyperglycemia can shorten the longevity of RBC,while the variation of RBC longevity leads to the deviation of HbA_(1)c from the true level.It is an urgent task to correct the effect of RBC longevity on HbA_(1)c level in clinical practice.This paper reviews the research progress of the effect of RBC longevity on HbA_(1)c level.

关 键 词：糖尿病 2型 糖化血红蛋白 红细胞寿命 变异 

分 类 号：R587.1[医药卫生—内分泌]