Notch信号通路对糖尿病肾脏疾病发生发展作用的研究进展  

Research progress of Notch signaling pathway in diabetic kidney disease

作　　者：张慧[1] 梁栋 林千愉 张晓敏[1] 都鹏超 ZHANG Hui;LIANG Dong;LIN Qianyu(Department of Nephrology,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院肾内科,256600

出　　处：《中国糖尿病杂志》2021年第10期790-794,共5页Chinese Journal of Diabetes

基　　金：山东省自然科学基金面上项目(2R2020MH080);山东省医药卫生科技发展项目(2017WS689)。

摘　　要：Notch信号通路在机体发育和调节稳态的过程中起重要作用,其在成熟肾脏中的重新激活对DKD发生发展起关键作用,包括足细胞损伤、肾小管间质纤维化及可能的血管生成和免疫系统激活。本文对Notch信号通路对DKD发生发展作用的研究进展进行综述,为临床治疗DKD提供依据。Notch signaling pathway is very important in body development and homeostasis regulation.Its reactivation plays a key role in the development of diabetic kidney disease(DKD)in mature kidney,including podocyte injury,tubulointerstitial fibrosis,angiogenesis and immune system activation.Here,we reviewed the research progress of Notch signaling pathway in DKD,and provided the evidence for DKD treatment in clinical practice.

关 键 词：糖尿病肾脏疾病 NOTCH信号通路 足细胞 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]