硫酸镁加拉贝洛尔联合低分子肝素钠治疗重度PIH对患者血压水平及母婴结局的影响  

Effect of magnesium sulfate galabellol combined with low molecular weight heparin on blood pressure and maternal and infant outcomes in patients with severe PIH

作　　者：张玉滢 袁洁婷 陈桂兰 韩俊 徐翀 Zhang Yuying;Yuan Jieting;Chen Gui Ian;Han Jun;Xu Chong(Shi ling Town Health Center,Huadu District,Guangzhou,Guangdong 510800,China;Guangzhou Hospital of integrated traditional Chinese and Western medicine,Guangzhou,Guangdong 510800,China)

机构地区：[1]广州市花都区狮岭镇卫生院,广东广州510800 [2]广州市中西医结合医院,广东广州510800

出　　处：《首都食品与医药》2021年第21期97-99,共3页Capital Food Medicine

摘　　要：目的考察硫酸镁加拉贝洛尔联合低分子肝素钠治疗重度妊娠高血压综合征(PIH)患者的疗效及对母婴结局的影响。方法选取本院2019年1月-2020年12月收治的110例重度PIH患者随机分成实验组(54例)和对照组(56例),对照组给予硫酸镁和拉贝洛尔治疗,实验组在对照组的基础.上加低分子肝素钠治疗。比较治疗前及治疗1周后两组血压[收缩压(SYS)、舒张压(DIA)]和凝血功能指标[血小板计数(PLT)、凝血酶时间(TT)]变化情况;记录治疗过程中出现的药物不良反应情况;随访至患者分娩,记录产妇结局和新生儿结局。结果治疗1周后,两组SYS.DIA.PLT水平较治疗前均有明显降低,且实验组明显低于对照组,组间同一时间相比具有显著性差异(P<0.05);两组T水平有明显升高,且实验组明显高于对照组,组间同一时间相比有显著性差异(P<0.05)。治疗1周内,实验组药物不良反应总发生率少于对照组,但差异无统计学意义(P>0.05)。治疗后随访至患者分娩,实验组自然分娩率明显高于对照组(P<0.05);两组子宫收缩过度、宫颈裂伤、胎儿窒息、围产儿死亡率比较差异均无统计学意义(P>0.05);实验组新生儿的出生体重、胎龄及Apgar评分皆明显高于对照组(P<0.05)。结论硫酸镁加拉贝洛尔联合低分子肝素钠治疗重度PIH效果良好,可明显改善凝血功能,更有利于保护母婴安全,并且用药方案安全性良好。Objective To investigate the rurative effect of magnesium sulfate galahellol romhined with low molecular weight heparin sodium in the treatment of severe pregnanc y induced hypertension(PIH)and its influence on maternal and infant outcomes.Methods 110 patients with severe PIH in our hospital from January 2019 to December 2020 were randomly divided into experimental group(54 cases)and rontrol group(56 rases).The rontrol group was treated with magnesium sulfate and lahetalol,and the experimenlal group was treated with low molerular weight heparin sodium on the basis of the control group.The changes of blood pressure[systolic hlooci pressure(sys),diastolic blood pressure(DIA)]and coagulation function indexes[platelet count(PLT),thrombin time(TT)]were compartnl between the two groups before and 1 week after treatment;the adverse drug reac tions during Ireatment were recorded;the patients were followed up to delivery,and the maternal and neonatal outcomes were recorded.Resu I ts After one week of treatment,the levels of sys,DIA and PLT in the two groups were significanlly lower than those before treatment,and the experimental group was significantly lower than thal in the control group,with signifirant difTerenre between the two groups at the same lime(P<0.05).The level of TT in ihe two groups was significantly higher than that in the rontrol group,with significant differenre between the two groups at the same time(P<0.05).Within one week of treatment,the total inridenre of adverse drug reactions in the experimental group was less than that in the rontrol group,hut the difference was not statistically signifirant(P>0.05).After treatment,follow-up to delivery,the natural delivery rate of the experimental group was significantly higher than that of the control group(P<0.05):there was no significant differenc e in uterine contraction,cervical laceration,fetal asphyxia,perinatal mortality between the two groups(P>0.05);the birth weight,gestational age and Apgar score of the experimental group were significantly higher tha

关 键 词：低分子肝素 重度妊娠高血压 硫酸镁 拉贝洛尔 

分 类 号：R714.246[医药卫生—妇产科学]