长期应用抗生素在支气管扩张症中的有效性和安全性研究进展  

Research progress in efficiency and safety of long-term antibiotics in bronchiectasis management

作　　者：张慧娟[1] 韩秀迪[1] 刘学东[1] Zhang Huijuan;Han Xiudi;Liu Xuedong(Department of Respiratory and Critical Care Medicine,Qingdao Municipal Hospital,Qingdao 266000,China)

机构地区：[1]青岛市市立医院呼吸与危重症医学科,266000

出　　处：《国际呼吸杂志》2021年第20期1597-1600,共4页International Journal of Respiration

摘　　要：支气管扩张症是指支气管管壁纤维及弹性组织被破坏,发生病理性永久性扩张,进而导致慢性气道感染、反复急性加重,住院率、病死风险增加,加重了医疗负担和家庭经济负担。近年研究显示长期应用抗生素可显著改善气道炎症和临床症状,降低急性加重频率和病死风险。然而目前国内支气管扩张症的管理仍偏重于急性加重期治疗,缺乏长期应用抗生素的管理指南。本文将长期应用抗生素在支气管扩张症中最新研究进展进行综述。Bronchiectasis is a condition in which bronchial wall fibers and elastic tissues are destructed,resulting in pathological permanent dilatation,which associates with chronic airway infection,repeated acute exacerbation,increased hospitalization rate and mortality,and heaveys burden of medical and family economy.Recent studies showed that long-term antibiotics significantly improved airway inflammation and clinical symptoms,decreased exacerbation and mortality.However,domestic bronchiectasis management inclines more to handle acute exacerbation rather than long-term antibiotic guidelines.Thus,the review focuses at the research progress of long-term antibiotics in bronchiectasis management.

关 键 词：支气管扩张症 抗菌药 药物疗法 疗效比较研究 

分 类 号：R562.22[医药卫生—呼吸系统]