辛伐他汀片联合依那普利叶酸片治疗高血压合并高同型半胱氨酸血症患者的回顾性研究  

Retrospective Study of Simvastatin Tablets Combined With Enalapril Folic Acid Tablets in the Treatment of Patients With Hypertension and Hyperhomocysteinemia

作　　者：李广运[1] Li Guangyun(Department of Cardiology,Nanyang Second People's Hospital,Nanyang473000,China)

机构地区：[1]南阳市第二人民医院心血管内科,河南南阳473000

出　　处：《哈尔滨医药》2021年第5期3-5,共3页Harbin Medical Journal

摘　　要：目的探究辛伐他汀片联合依那普利叶酸片治疗高血压合并高同型半胱氨酸(Hcy)血症(HHT)患者的疗效。方法对60例的临床资料进行回顾性分析,采用依那普利叶酸片治疗的30例为常规组,采用辛伐他汀片联合依那普利叶酸片治疗的30例为联合组。对比两组疗效及治疗前后舒张压(DBP)、收缩压(SBP)、血清Hcy、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、基质金属蛋白酶9(MMP-9)水平。结果联合组总有效率93.33%高于常规组66.67%(P<0.05);治疗后联合组DBP、SBP、血清Hcy水平低于常规组(P<0.05);治疗后联合组血清TNF-α、CRP、MMP-9水平低于常规组(P<0.05)。结论辛伐他汀片联合依那普利叶酸片治疗HHT患者,可降低血清Hcy及炎症因子水平,提高血压控制效果,效果显著。Objective To explore the efficacy of simvastatin tablets combined with enalapril folic acid tablets in the treatment of patients with hypertension and hyperhomocysteinemia(HHT).Methods The clinical data of 60 patients with HHT were retrospectively analyzed.30 patients were treated with enalapril folic acid tablets as the conventional group,and 30 patients treated with simvastatin tablets and enalapril folic acid tablets as the combined group.The curative effects of the two groups were compared and the levels of diastolic blood pressure(DBP),systolic blood pressure(SBP),serum Hcy,tumor necrosis factorα(TNF-α),C-reactive protein(CRP)and matrix metalloproteinase-9(MMP-9)levels were compared between the two groups before and after treatment.Results The total effective rate of the combined group was 93.33% higher than that of the conventional group 66.67%(P<0.05);after treatment,the levels of DBP,SBP and serum Hcy in the combined group were lower than those in the conventional group(P<0.05);after treatment,the levels of TNF-α,CRP and MMP-9 in the combined group were lower than those in the conventional group(P<0.05).Conclusion Simvastatin tablets combined with enalapril folic acid tablets in the treatment of HHT patients can reduce the levels of serum Hcy and inflammatory factors,improve the effect of blood pressure control,with a significant effect.

关 键 词：辛伐他汀片 依那普利叶酸片 高同型半胱氨酸血症 高血压 炎症因子 

分 类 号：R696.4[医药卫生—泌尿科学]