线粒体对卵母细胞发育的影响  

Effects of mitochondria on oocyte development

作　　者：安卓 谢聪聪 赵明[1] 王雪莹 王树松 尚丹丹[1] AN Zhuo;XIE Cong-cong;ZHAO Ming;WANG Xue-ying;WANG Shu-song;SHANG Dan-dan(Graduate School of Hebei Medical University,Shijiazhuang 050017;Research Institute of Family Planning of Hebei Province,Hebei Reproductive Hospital,Key Laboratory for Family Planning and Birth Health of the National Health and Family Planning Committee/Key Laboratory of Reproductive Medicine of Hebei Province,Shijiazhuang 050071)

机构地区：[1]河北医科大学研究生院,石家庄050017 [2]河北省计划生育科学技术研究院,河北省生殖医院,国家卫生健康委员会计划生育与优生重点实验室/河北省生殖医学重点实验室,石家庄050071

出　　处：《生殖医学杂志》2021年第11期1533-1537,共5页Journal of Reproductive Medicine

基　　金：河北省医学科学研究课题(20190144)。

摘　　要：卵母细胞质量是评估女性生育能力的关键指标。随着年龄增加,卵母细胞的发育潜能逐渐下降,卵母细胞质量也会显著降低。线粒体是影响卵母细胞质量的关键指标。线粒体的形态结构、生物发生、线粒体DNA拷贝数、膜电位、能量产生和清除活性氧(ROS)的能力都与卵母细胞的发育息息相关。本文就线粒体对卵母细胞发育的影响进行综述。Oocyte quality is a key indicator of female fertility.With the increase of age,the development potential of oocyte decreases,and the oocyte quality decreases significantly as well.Mitochondria is one of the key indicators of oocyte quality.The morphological structure of mitochondria,biogenesis,mtDNA copy number,membrane potential,energy production and the ability to eliminate reactive oxygen species(ROS)are closely related to oocyte development.In this paper,the effects of mitochondria on the oocyte quality is reviewed.

关 键 词：卵母细胞 线粒体 线粒体DNA 线粒体膜电位 三磷酸腺苷 

分 类 号：R711.6[医药卫生—妇产科学]