温阳祛痰法联合二甲双胍治疗PCOS所致闭经临床观察  

Clinical Observation on Warming Yang and Expelling Phlegm Method Combined with Metformin on PCOS-induced Amenorrhea

作　　者：范本本 武晓燕 FAN Benben;WU Xiaoyan(Department of Internal Medicine-Oncology,the First Affiliated Hospital of Henan University of Science and Technology,Henan Province,Luoyang 471003,China;Department of Obstetrics and Gynecology,Ruzhou Maternal and Child Health Hospital,Henan Province,Ruzhou 467599,China)

机构地区：[1]河南科技大学第一附属医院肿瘤内科,河南洛阳471003 [2]汝州市妇幼保健院妇产科,河南汝州467599

出　　处：《光明中医》2021年第19期3331-3334,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

摘　　要：目的探讨温阳祛痰法联合二甲双胍治疗PCOS所致闭经的疗效及对性激素、胰岛素抵抗的影响。方法选取2019年2月—2020年5月接受治疗的PCOS所致闭经患者78例,经随机数字表法分为西医组、中西医结合组各39例。西医组患者接受常规西医+二甲双胍治疗、中西医结合组患者在对照组治疗方案基础上加入温阳祛痰法治疗。对比2组治疗效果及外周血性激素、胰岛素抵抗相关指标水平的差异。结果治疗后,中西医结合组的治疗总有效率为97.44%,显著高于西医组患者的84.62%(P<0.05)。中西医结合组外周血中LH、T水平低于西医组,FSH、E_(2)水平高于西医组;外周血中FPG、FINS、HOMA-IR水平低于西医组(P<0.05)。用药期间,2组患者恶心呕吐、腹泻便秘、头晕头痛、皮疹红斑的发生率差异无统计学意义(P>0.05)。2组无1例发生心律失常、肝功能损伤、肾功能损伤。结论PCOS所致闭经患者在二甲双胍治疗同时加入中医温阳祛痰法进行联合治疗,在提升整体疗效及优化内分泌指标方面均具有优势。Objective To investigate the efficacy of warming yang and expelling phlegm combined with metformin on PCOS-induced amenorrhea and their effect on sex hormone and insulin resistance.Methods 78 cases of PCOS-induced amenorrhea patients in our hospital during February 2019 to May 2020 were divided into western medicine group(n=39,underwent western medicine treatment)and combined group(n=39,underwent traditional Chinese and western medicine treatment)according to random number table.The difference between two groups in treatment efficacy,peripheral blood hormones and insulin resistance were compared.Results After treatment,the effective rate of combined group was 97.44%,which was significantly higher than that of western medicine group(84.62%)(P<0.05).Levels of LH and T in peripheral blood of combined group were lower than those of western medicine group,FSH and E2 were higher than those of western medicine group,and levels of FPG,FINS and HOMA-IR in peripheral blood of the combined group were lower than those of western medicine group(P<0.05).During the medication period,there were no statistically significant difference in the incidence of nausea,vomiting,diarrhea,constipation,dizziness,headache and rash and erythema between two groups(P>0.05).No arrhythmia,liver function injury and renal function injury occurred in two groups.Conclusion PCOS-induced amenorrhea patients treated with warming yang and expelling phlegm method have advantages in improving overall efficacy and optimizing endocrine indicators.

关 键 词：多囊卵巢综合征 闭经 温阳祛痰法 二甲双胍 中西医结合疗法 

分 类 号：R711.75[医药卫生—妇产科学]