双刺激方案在卵巢低反应患者中的应用研究进展  

Recent advances of double stimulation protocols in poor ovarian responders

作　　者：李京哲 高敏芝[1] Li Jingzhe;Gao Minzhi(Center for Reproductive Medicine,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics,Shanghai 200135,China)

机构地区：[1]上海交通大学医学院附属仁济医院生殖中心上海市辅助生殖与优生重点实验室,200135

出　　处：《中华生殖与避孕杂志》2021年第9期839-842,共4页Chinese Journal of Reproduction and Contraception

基　　金：中华医学会临床医学科研专项资金(18010370766)。

摘　　要：卵巢低反应(poor ovarian response,POR)是一种生殖内分泌疾病,患者行体外受精促排卵后的获卵数往往较低,严重影响妊娠成功率。双刺激方案利用黄体期卵巢刺激的原理,通过在一个月经周期内二次取卵,短时间内可以获取更多数量的卵子。因此,进一步探索这种新的促排卵方案可能有助于为POR患者提供更好的治疗策略。本文从POR定义、双刺激方案的作用机制和发展历史,以及在POR患者中的应用进行综述。Poor ovarian response(POR)is a reproductive endocrinology disease that seriously affects the number of oocytes retrieved and reduces the success rate of in vitro fertilization(IVF).The double stimulation protocol utilizes the principle of ovarian stimulation in both the follicular and luteal phase.By retrieving oocytes within one menstrual cycle,more oocytes can be obtained in a fairly short period of time.Therefore,to further explore this new ovarian stimulation protocol may help to provide better treatment strategies for POR patients.This paper reviews the definition of POR,the mechanism and developments of double stimulation,and its application in POR patients.

关 键 词：卵巢低反应 黄体期刺激 冷冻胚胎移植 双刺激方案 

分 类 号：R714.8[医药卫生—妇产科学]