Traditional Chinese medicine for gait disturbance in adrenoleukodystrophy:A case report and review of literature  

作　　者：Hyungsuk Kim Taeoh Kim Whisung Cho Hokyung Chang Won-Seok Chung 

机构地区：[1]Department of Korean Medicine Rehabilitation,Kyung Hee University,Seoul 02447,South Korea

出　　处：《World Journal of Clinical Cases》2021年第31期9691-9698,共8页世界临床病例杂志

基　　金：Supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI)(funded by the Ministry of Health&Welfare of the Republic of Korea),No.HI20C1405.

摘　　要：BACKGROUND Adrenoleukodystrophy(ALD)is caused by a deficit in the ABCD1 gene,which leads to demyelination of neurons and dysfunction of the adrenal cortices and testicles.Of the three known phenotypes,30%-50%of male ALD patients present with the adrenomyeloneuropathy phenotype,characterized by gait disturbance as the initial symptom.CASE SUMMARY A 46-year-old man with a prior diagnosis of ALD was admitted to a Korean medicine hospital for the treatment of gait disturbance.His ability to walk was severely impaired at admission,significantly affecting the patient’s quality of life.He was treated with acupuncture,pharmacopuncture,electroacupuncture,and herbal medicine for 23 d.The 25-Foot Walk test(25FW),timed up and go(TUG),comfortable gait speed(CGS),numeric rating scale(NRS),Berg Balance Scale(BBS),Tinetti test,manual muscle test(MMT),and 3-level version of EuroQol-5 dimension(EQ-5D-3L)were used to evaluate the patient.The outcomes of the 25FW,TUG,and CGS improved during hospitalization.From the time of admission to discharge we observed:A decrease in NRS scores in the lower extremities and the lower back;an increase of 3 points in the BBS;a 1-point increase in the balancing part of the Tinetti Test;MMT and EQ-5D-3L performances remained unchanged.CONCLUSION Traditional Chinese medicine treatments could be a therapeutic option to alleviate issues related to gait disturbance in ALD.

关 键 词：Traditional Chinese medicine Herbal medicine Gait disturbance ADRENOLEUKODYSTROPHY Adenosine triphosphate Case report 

分 类 号：R259[医药卫生—中西医结合]