甲巯咪唑与丙硫氧嘧啶治疗甲亢的疗效及对肝功能的影响分析  

Analysis of the efficacy of thiamazole and propylthiouracil in the treatment of hyperthyroidism and its influence on liver function

作　　者：姜涛 JIANG Tao(Gaizhou Bohai Hospital,Yingkou 115200,China)

机构地区：[1]辽宁省营口市盖州博海医院,115200

出　　处：《中国现代药物应用》2021年第20期146-148,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析在甲状腺功能亢进症(甲亢)治疗中应用丙硫氧嘧啶和甲巯咪唑的临床疗效及对肝功能的影响。方法98例甲亢患者,以治疗药物不同分为对照组及实验组,各49例。对照组采用丙硫氧嘧啶治疗,实验组采用甲巯咪唑治疗。对比两组的临床治疗效果、肝功能指标[总胆红素(TBIL)、碱性磷酸酶(ALP)、丙氨酸转氨酶(ALT)]及不良反应发生情况。结果实验组治疗总有效率95.92%高于对照组的81.63%,差异有统计学意义(P<0.05)。治疗后,实验组TBIL(14.15±1.70)μmol/L、ALP(36.85±4.20)U/L、ALT(21.65±3.11)U/L均低于对照组的(16.65±1.85)μmol/L、(39.65±4.35)U/L、(24.20±3.25)U/L,差异有统计学意义(P<0.05)。实验组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论甲亢治疗中应用甲巯咪唑可获得满意的治疗效果,较小影响肝功能,建议推广。Objective To analyze the clinical efficacy of thiamazole and propylthiouracil in the treatment of hyperthyroidism and its influence on liver function.Methods A total of 98 patients with hyperthyroidism were divided into control group and experimental group according to different drugs,with 49 cases in each group.The control group was treated with propylthiouracil,and the experimental group was treated with thiamazole.Both groups were compared in terms of clinical effect,liver function indexes[total bilirubin(TBIL),alkaline phosphatase(ALP),alanine aminotransferase(ALT)],and the incidence of adverse reactions.Results The total effective rate of treatment 95.92%in the experimental group was higher than 81.63%in the control group,and the difference was statistically significant(P<0.05).After treatment,TBIL(14.15±1.70)μmol/L,ALP(36.85±4.20)U/L,and ALT(21.65±3.11)U/L of the experimental group were lower than(16.65±1.85)μmol/L,(39.65±4.35)U/L,(24.20±3.25)U/L of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of thiamazole in the treatment of hyperthyroidism can obtain satisfactory therapeutic effects with less impact on liver function,and is recommended to be promoted.

关 键 词：甲状腺功能亢进症 甲巯咪唑 丙硫氧嘧啶 肝功能 

分 类 号：R581.1[医药卫生—内分泌]