Botulinum toxin associated with fissurectomy and anoplasty for hypertonic chronic anal fissure: A case-control study  

作　　者：Beatrice D'Orazio Girolamo Geraci Fausto Famà Gloria Terranova Gaetano Di Vita 

机构地区：[1]Department of Surgical,Oncological and Stomatological Sciences,University of Palermo,Palermo 90100,Sicily,Italy [2]Department of Human Pathology in Adulthood and Childhood"G.Barresi",University Hospital of Messina,Messina 98121,Sicily,Italy [3]Department of Surgical,Oncological and Stomatological Sciences,Postgraduate Medical School in General Surgery,University of Palermo,Palermo 90100,Sicily,Italy

出　　处：《World Journal of Clinical Cases》2021年第32期9722-9730,共9页世界临床病例杂志

摘　　要：BACKGROUND Lateral internal sphincterotomy is still the approach of choice for the treatment of chronic anal fissure(CAF)with internal anal sphincter(IAS)hypertonia,but it is burdened by high-risk postoperative faecal incontinence(FI).Sphincter saving procedures have recently been reconsidered as treatments to overcome this risk.The most employed procedure is fissurectomy with anoplasty,eventually associated with pharmacological sphincterotomy.AIM To evaluate whether fissurectomy and anoplasty with botulinum toxin injection improves the results of fissurectomy and anoplasty alone.METHODS We conducted a case-control study involving 30 male patients affected by CAF with hypertonic IAS who underwent fissurectomy and anoplasty with V-Y cutaneous flap advancement.The patients were divided into two groups:Those in group I underwent surgery alone,and those in group II underwent surgery and a botulinum toxin injection directly into the IAS.They were followed up for at least 2 years.The goals were to achieve complete healing of the patient and to assess the FI and recurrence rate along with manometry parameters.RESULTS The intensity and duration of post-defecatory pain decreased significantly in both groups of patients starting with the first defecation,and this reduction was higher in group II.Forty days after surgery,we achieved complete wound healing in all the patients in group II but only in 80%of the patients in group I(P<0.032).We recorded 2 cases of recurrence,one in each group,and both healed with conservative therapy.We recorded one temporary and low-grade postoperative case of“de novo”FI.Manometry parameters reverted to the normal range earlier for group II patients.CONCLUSION The injection of botulinum toxin A in association with fissurectomy and anoplasty with a V-Y advancement flap improves the results of surgery alone in patients affected by CAF with IAS hypertonia.

关 键 词：PROCTOLOGY FISSURECTOMY ANOPLASTY Anal fissure Botulinum toxin 

分 类 号：R657.14[医药卫生—外科学]