Endoscopic anti-reflux therapy for gastroesophageal reflux disease  

作　　者：Enrique Rodríguez de Santiago Eduardo Albéniz Fermin Estremera-Arevalo Carlos Teruel Sanchez-Vegazo Vicente Lorenzo-Zúñiga 

机构地区：[1]Department of Gastroenterology and Hepatology,Hospital Universitario Ramón y Cajal,Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS),Madrid 28034,Spain [2]Endoscopy Unit,Gastroenterology Department,Hospital Universitario de Navarra.Gastrointestinal Endoscopy Research Unit,Navarrabiomed Biomedical Research Center.Pamplona,Spain [3]Endoscopy Unit,Gastroenterology Department,Hospital Universitari i Politècnic La Fe,Instituto de Investigación Sanitaria La Fe(IIS La Fe),Valencia 46026,Spain

出　　处：《World Journal of Gastroenterology》2021年第39期6601-6614,共14页世界胃肠病学杂志（英文版）

摘　　要：Gastroesophageal reflux disease has an increasing incidence and prevalence worldwide.A significant proportion of patients have a suboptimal response to proton pump inhibitors or are unwilling to take lifelong medication due to concerns about long-term adverse effects.Endoscopic anti-reflux therapies offer a minimally invasive option for patients unwilling to undergo surgical treatment or take lifelong medication.The best candidates are those with a good response to proton pump inhibitors and without a significant sliding hiatal hernia.Transoral incisionless fundoplication and nonablative radiofrequency are the techniques with the largest body of evidence and that have been tested in several randomized clinical trials.Band-assisted ligation techniques,anti-reflux mucosectomy,antireflux mucosal ablation,and new plication devices have yielded promising results in recent noncontrolled studies.Nonetheless,the role of endoscopic procedures remains controversial due to limited long-term and comparative data,and no consensus exists in current clinical guidelines.This review provides an updated summary focused on the patient selection,technical details,clinical success,and safety of current and future endoscopic anti-reflux techniques.

关 键 词：Treatment Gastroesophageal reflux Transoral incisionless fundoplication Anti-reflux mucosectomy Anti-reflux mucosal ablation Stretta 

分 类 号：R655.4[医药卫生—外科学]