Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis  

作　　者：Evanthia Perikleous Sotirios Fouzas Athina Karageorgiou Paschalis Steiropoulos Evangelia Nena Athanasios Chatzimichael Aggelos Tsalkidis Emmanouil Paraskakis 

机构地区：[1]Department of Pediatrics,University General Hospital of Alexandroupolis,Democritus University of Thrace,Alexandroupoli 68100,Greece [2]Department of Paediatrics,University Hospital of Patras,University of Patras,Patra 26504,Greece [3]Department of Pneumonology,University General Hospital of Alexandroupolis,Democritus University of Thrace,Alexandroupoli 68100,Greece [4]Laboratory of Hygiene and Environmental Protection,Medical School,Democritus University of Thrace,Alexandroupoli 68100,Greece [5]Paediatric Respiratory Unit,Paediatric Department,University of Crete,Heraklion 71500,Greece

出　　处：《World Journal of Clinical Pediatrics》2021年第6期168-176,共9页世界临床儿科杂志

摘　　要：BACKGROUND Tidal breathing flow-volume(TBFV)analysis provides important information about lung mechanics in infants.AIM To assess the effects of breastfeeding on the TBFV measurements of infants who recover from acute bronchiolitis.METHODS In this cross-sectional study,TBFV analysis was performed in infants with bronchiolitis prior to hospital discharge.The ratio of time to peak expiratory flow to total expiratory time(tPEF/tE)at baseline and after the administration of 400 mcg salbutamol was evaluated.RESULTS A total of 56 infants(35 boys),aged 7.4±2.8 mo,were included.Of them,12.5%were exposed to tobacco smoke and 41.1%were breastfed less than 2 mo.There were no differences in baseline TBFV measurements between the breastfeeding groups;however,those who breastfed longer than 2 mo had a greater change in tPEF/tE after bronchodilation(12%±10.4%vs 0.9%±7.1%;P<0.001).Moreover,there was a clear dose-response relationship between tPEF/tE reversibility and duration of breastfeeding(P<0.001).In multivariate regression analysis,infants who breastfed less(regression coefficient-0.335,P=0.010)or were exposed to cigarette smoke(regression coefficient 0.353,P=0.007)showed a greater change in tPEF/tE after bronchodilation,independent of sex,prematurity,and family history of asthma or atopy.CONCLUSION Infants who recover from bronchiolitis and have a shorter duration of breastfeeding or are exposed to cigarette smoke,have TBFV measurements indicative of obstructive lung disease.

关 键 词：Tidal breathing analysis Lung function BRONCHIOLITIS BREASTFEEDING Cigarette smoke INFANTS 

分 类 号：R725.6[医药卫生—儿科]