血小板平均体积、红细胞分布宽度与SYNTAXⅡ积分在非ST段抬高型急性冠脉综合症患者中的相关性  

The correlation of mean platelet volume and red blood cell distribution width with SYNTAX scoreⅡin patients with non-ST-segment elevation acute coronary syndrome

作　　者：王博 朱春甲[1] WANG Bo(Department of Cardiology,Tongling People’s Hospital,Tongling 244000,China)

机构地区：[1]铜陵市人民医院心内科,安徽铜陵244000

出　　处：《牡丹江医学院学报》2021年第6期82-86,共5页Journal of Mudanjiang Medical University

摘　　要：目的本研究探讨血小板平均体积(Mean platelet volume,MPV)和红细胞分布宽度(Red cell distribution width,RDW)与非ST段抬高型急性冠脉综合症(Non-ST-segment elevation acute coronary syndrome,NSTE-ACS)患者SYNTAXⅡ积分(SYNTAX scoreⅡ,SS-Ⅱ)的相关性。方法入选我院2018年1月1日至2020年1月1日行定量冠状动脉造影检查明确诊断为NSTE-ACS患者209例。通过造影结果进行SYNTAXⅡ评分并依据积分分为低危组51例(≤23分)、中危组72例(>23且≤31分)和高危组86例(>31分)。定量冠脉造影前对所有患者进行血常规及血生化检测。比较各组患者MPV和RDW之间的差异。分析患者MPV和RDW与SYNTAXⅡ积分的相关性。结果SYNTAXⅡ积分高危组的MPV数值显著大于低位组和中危组患者[(12.48±1.35)fl vs(10.45±1.29)fl,(11.78±1.25)fl,P<0.001]。SYNTAXⅡ积分高危组患者RDW显著大于低、中危组患者[(14.09±0.94)%vs(12.63±0.68)%,(13.41±0.77)%,P<0.001]。NSTE-ACS患者MPV和RDW水平与SYNTAXⅡ积分呈正相关性(r=0.467,P<0.001;r=0.650,P<0.001)。ROC曲线分析,当MPV截点值为11.95fl,预测SYNTAXⅡ积分高危的敏感性为67.4%,特异性为74.8%,AUC为0.756[95%CI(0.689,0.824),P<0.001)]。当RDW截点值为13.25%,预测SYNTAXⅡ积分高危的敏感性为81.4%,特异性为59.3%,AUC为0.793[95%CI(0.733,0.853),P<0.001)]。结论MPV和RDW与NSTE-ACS患者SYNTAXⅡ积分存在显著的正相关性,其对NSTE-ACS患者冠状动脉病变严重程度及PCI远期预后具有一定的预测价值。To evaluate the relationship between mean platelet volume(MPV),red cell distribution width(RDW)and SYNTAX scoreⅡ(SS-Ⅱ)in patients with non-ST-segment elevation acute coronary syndrome(NSTE-ACS).Methods 209 patients with non-ST-segment elevation acute coronary syndrome undergoing quantitative coronary arteriography were enrolled in the Tongling People’s Hospital from January 1st 2018 to January 1st 2020.The patients were stratified according to SS-Ⅱfor PCI:low-risk group(SS-Ⅱ≤23,n=51),medium-risk group(SS-Ⅱ>23 and SS-Ⅱ≤31,n=72),high-risk group(SS-Ⅱ>31,n=86).The blood routine and blood biochemical were tested before quantitative coronary arteriography.The values of MPV and RDW were compared among the three groups.The correlation of mean platelet volume and red blood cell distribution width with SS-Ⅱwere analyzed.Results Compared with low-risk and medium-risk groups,the MPV level in high-risk group was significantly higher[(12.48±1.35)fl vs(10.45±1.29)fl,(11.78±1.25)fl,P<0.001].Compared with low-risk and medium-risk groups,the RDW level in high-risk group was significantly higher[(14.09±0.94)%vs(12.63±0.68)%,(13.41±0.77)%,P<0.001].MPV and RDW were significantly associated with SS-Ⅱ(r=0.467,P<0.001;r=0.650,P<0.001).By ROC curve analysis,an MPV value higher than 11.95fl,had 67.4%sensitivity and 74.8%specificity in forecasting high-risk of SS-Ⅱ[AUC:0.756,95%CI(0.689,0.824),P<0.001].An RDW higher than 13.25%has 81.4%sensitivity and 59.3%specificity in forecasting high-risk of SS-Ⅱ[AUC,0.793;95%CI(0.733,0.853),P<0.001].Conclusion High MPV and RDW level is independently and significantly correlated with high-risk of SS-Ⅱin NSTE-ACS patients,which can help to judge the risk stratification and long-term prognosis of NSTE-ACS patients.

关 键 词：血小板平均体积 红细胞分布宽度 SYNTAXⅡ积分 非ST段抬高型急性冠脉综合症 

分 类 号：R541.4[医药卫生—心血管疾病]