Cascaded amplification of intracellular oxidative stress and reversion of multidrug resistance by nitric oxide prodrug based-supramolecular hydrogel for synergistic cancer chemotherapy  

作　　者：Jimin Zhang Meigui Deng Xiaoguang Shi Chuangnian Zhang Xiongwei Qu Xiuli Hu Weiwei Wang Deling Kong Pingsheng Huang 

机构地区：[1]Hebei Key Laboratory of Functional Polymers,National-Local Joint Engineering Laboratory for Energy Conservation of Chemical Process Integration and Resources Utilization,School of Chemical Engineering and Technology,Hebei University of Technology,Tianjin,300130,China [2]Tianjin Key Laboratory of Biomaterial Research,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,300192,China [3]State Key Laboratory of Medicinal Chemical Biology,College of Life Sciences,Nankai University,Tianjin,300071,China

出　　处：《Bioactive Materials》2021年第10期3300-3313,共14页生物活性材料（英文）

基　　金：We acknowledge the financial support from the National Natural Science Foundation of China(No.U20A20260,51973213);Natural Science Foundation of Hebei Province(C20202006)。

摘　　要：1.Introduction Chemotherapy is the traditional treatment for clinical cancer patient[1,2].However,the therapeutic effect is often severely limited by the multidrug resistance(MDR)[3,4],which was commonly mediated by inactivating drugs,increasing efflux,stimulating DNA repair mechanisms,and/or activating detoxification pathways[5-7].Recent studies are committing to develop reasonable strategies for intervention of the molecular pathways mediating MDR,of which P-glycoprotein(P-gp)has been widely investigated[8].So far,several kinds of P-gp inhibitors,including verapamil[9],vitamin E[10],cyclosporin A[11],and small interfering RNA(siRNA)[12].

关 键 词：NO prodrug Supramolecular hydrogel Oxidative stress Multidrug resistance Synergistic therapy 

分 类 号：R318.08[医药卫生—生物医学工程] R730.5[医药卫生—基础医学]