Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivo and in vitro  

作　　者：Xiaoyu Huang Yang Ge Bina Yang Qi Han Wen Zhou Jingou Liang Mingyun Li Xian Peng Biao Ren Bangcheng Yang Michael D.Weir Qiang Guo Haohao Wang Xinxuan Zhou Xugang Lu Thomas W.Oates Hockin H.K.Xu Dongmei Deng Xuedong Zhou Lei Cheng 

机构地区：[1]State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,National Clinical Research Center for Oral Diseases,Sichuan University,Chengdu,610041,China [2]Department of Operative Dentistry and Endodontics,West China School of Stomatology,Sichuan University,Chengdu,610041,China [3]Stomatological Hospital,Southern Medical University,Guangzhou,510280,China [4]Department of Pathology,West China School of Stomatology,Sichuan University,Chengdu,610041,China [5]Department of Pediatrics,West China School of Stomatology,Sichuan University,Chengdu,610041,China [6]Department of Advanced Oral Sciences and Therapeutics,University of Maryland School of Dentistry,Baltimore,MD,21201,USA [7]Department of Preventive Dentistry,Academic Center for Dentistry Amsterdam(ACTA),University of Amsterdam and VU University Amsterdam,Amsterdam,the Netherlands [8]National Engineering Research Center for Biomaterials,Sichuan University,Chengdu,610041,China

出　　处：《Bioactive Materials》2021年第12期4568-4579,共12页生物活性材料（英文）

基　　金：This research was supported by the National Key Research and Development Program of China(2016YFC1102700,2016YFC1102701 X.Z);National Natural Science Foundation of China(81870759,82071106,L.C);Innovative Research Team Program of Sichuan Province(L.C).

摘　　要：Peri-implantitis are a major problem causing implant failure these days.Accordingly,anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue.Micro-arc oxidation(MAO)treatment is a way to form an oxidation film on the surface of metallic materials.The method shows good osteogenic properties but weak antibacterial effect.Therefore,we developed combined strategies to combat severe peri-implantitis,which included the use of a novel compound,PD,comprising dendrimers poly(amidoamine)(PAMAM)loading dimethylaminododecyl methacrylate(DMADDM)as well as MAO treatment.Here,we explored the chemical properties of the novel compound PD,and proved that this compound was successfully synthesized,with the loading efficiency and encapsulation efficiency of 23.91%and 31.42%,respectively.We further report the two-stage double benefits capability of PD+MAO:(1)in the first stage,PD+MAO could decrease the adherence and development of biofilms by releasing DMADDM in the highly infected first stage after implant surgery both in vitro and in vivo;(2)in the second stage,PD+MAO indicated mighty anti-infection and osteoconductive characteristics in a rat model of peri-implantitis in vivo.This study first reports the two-staged,double benefits of PD+MAO,and demonstrates its potential in clinical applications for inhibiting peri-implantitis,especially in patients with severe infection risk.

关 键 词：PERI-IMPLANTITIS Dimethylaminododecyl methacrylate Animal model OSSEOINTEGRATION Bioactive and therapeutic 

分 类 号：R318[医药卫生—生物医学工程] R78[医药卫生—基础医学]