结节性甲状腺肿的中医证候要素与CT平扫特征及灌注参数的相关性研究  

Study on the correlation between TCM syndrome elements of nodular goiter and CT imaging features and perfusion parameters

作　　者：冀春亮[1] 陈正光[1] JI Chunliang;CHEN Zhengguang(Department of Radiology,Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院放射科,北京100700

出　　处：《中国中西医结合影像学杂志》2021年第6期527-531,共5页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：教育部直属高校2019年青年教师项目(2019-JYB-JS-063)。

摘　　要：目的:探讨双源CT平扫及灌注成像在结节性甲状腺肿中医辨证分型中的应用价值。方法:搜集结节性甲状腺肿患者92例,依据中医证型进行分组,总结不同证型结节性甲状腺肿的CT平扫特征,分析灌注成像参数。纳入健康志愿者25例作为正常组,比较结节性甲状腺肿与正常组,以及各中医证型结节性甲状腺肿的血流量、血容量、表面通透性(PS)、平均通过时间(MTT)。结果:92例中,气滞组31例,痰凝组25例,血瘀组16例,阴虚组20例。气滞组多为单发结节,边界清楚;痰凝组多为多发结节,边界一般欠清楚,常有多发钙化灶;血瘀组多边界清楚,病变组织内常有点状钙化;阴虚组多发性结节多见。血瘀组的血流量、血容量与正常组比较,差异均有统计学意义(均P<0.05);气滞组的PS与正常组比较,差异有统计学意义(P<0.05);MTT组间比较,差异均无统计学意义(均P>0.05)。结论:双源CT平扫及灌注成像可为结节性甲状腺肿的中医辨证分型提供可参考的客观指标。Objective:To explore the value of dual-source CT plain scan and perfusion imaging in TCM syndrome differentiation of nodular goiter.Methods:A total of 92 patients with nodular goiter were collected and grouped according to the TCM syndromes.CT features of different groups were summarized.25 patients and 25 healthy volunteers were scanned by perfusion imaging,and the diseased tissues and normal tissue were analyzed and compared.Comparisons of blood flow(BF),blood volume(BV),surface permeability(PS),and mean transit time(MTT)between different TCM syndromes of nodular goiter were made.Results:In the qi stagnation group(31 cases),single nodules with clear boundaries were seen mostly.In the spittoon group(25 cases),multiple nodules with unclear edges and multiple calcification foci were usually shown.The boundaries of nodular were clear and punctate calcification was often found in the blood stasis group(16 cases).Multiple nodules were common in Yin deficiency group(20 cases).There were significant differences of blood flow and blood volume between the blood stasis group and the normal group(both P<0.05).There was also a significant difference of PS between the normal group and the qi stagnation group(P<0.05),but no statistical difference of MTT.Conclusions:Dual-source CT plain scan and perfusion imaging can provide objective indicators for the TCM syndrome differentiation of thyroid nodules.

关 键 词：甲状腺结节 体层摄影术 X线计算机 灌注成像 

分 类 号：R259[医药卫生—中西医结合]