SPOCK家族生物学功能的研究进展  

Research advance in the biological functions of SPOCK family

作　　者：陈阳 万波 周秀敏[1] CHEN Yang;WAN Bo;ZHOU Xiumin(Department of Oncology,the First Affiliated Hospital of Soochow University,Suzhou 215006;Research Institute of Neuroscience,Soochow University)

机构地区：[1]苏州大学附属第一医院肿瘤科,苏州215006 [2]苏州大学神经科学研究所

出　　处：《南通大学学报（医学版）》2021年第5期450-456,共7页Journal of Nantong University(Medical sciences)

基　　金：国家自然科学基金面上资助项目(81301906);苏州大学横向科研项目(H201033)。

摘　　要：SPOCK(SPARC/Osteonectin CWCV and Kazal-like domains proteoglycan)蛋白是高度保守的、多结构域的细胞外基质糖蛋白家族,主要由SPOCK1、SPOCK2、SPOCK33个家族成员组成。它们具有相似的N端、卵泡抑制素样结构域(follistatin,FS)、钙结合区(calcium-binding,EC)和C端,C端包含一个甲状腺球蛋白样结构域(thyroglobulin,TY)和Ⅴ结构域。近年来研究表明,SPOCK家族蛋白调节中枢神经系统的发育,且影响多种疾病的发生发展过程。本文主要对SPOCK家族蛋白的分子结构特点、组织分布、生物学功能及与疾病的关系进行综述。SPARC/Osteonectin CWCV and Kazal-like domains proteoglycan(SPOCK)is a highly conserved multi-domain extracellular matrix glycoprotein family,which mainly composed of SPOCK1,SPOCK2 and SPOCK3.They have similar N-terminal,follistatin(FS)domain,calcium-binding(EC)domain and C-terminal,the C-terminal contains thyroglobulin(TY)domain and domain V.Present studies have shown that SPOCK family proteins regulate the development of the central nervous system and affect the occurrence and development of a variety of diseases.In this article,the molecular structure characteristics,tissue distribution,biological function and the relationship between SPOCKs and diseases were reviewed.

关 键 词：SPOCK家族 细胞外基质 生物学功能 

分 类 号：Q513.2[生物学—生物化学]