Microarchitecture of titanium cylinders obtained by additive manufacturing does not influence osseointegration in the sheep  

作　　者：Louis Rony Eric Aguado Bruno Verlee Florence Pascaretti-Grizon Daniel Chappard 

机构地区：[1]GEROM-Groupe Etudes Remodelage Osseux et bioMate´riaux,LabCom NextBone,Univ-Angers,IRIS-IBS Institut de Biologie en Sante´,49933 Angers,France [2]ONIRIS,Ecole Ve´te´rinaire de Nantes,44307,Nantes Cedex 3,France [3]SIRRIS Lie`ge Science Park,Rue du bois St Jean 12,Seraing 4102,Belgium [4]SCIAM,Service Commun d’Imagerie et Analyses Microscopiques,IRIS-IBS Institut de Biologie en Sante´,Univ-Angers,Angers Cedex 49933,France

出　　处：《Regenerative Biomaterials》2021年第4期11-20,共10页再生生物材料（英文版）

基　　金：This work was supported partially by the Walloon Region(CWALity project NEXTBONE:Convention n_1610093).This work was made possible by grants from the CHU of Angers(University hospital),project MOCONA and the French Ministry of Research.

摘　　要：Large bone defects are a challenge for orthopedic surgery.Natural(bone grafts)and synthetic biomaterials have been proposed but several problems arise such as biomechanical resistance or viral/bacterial safety.The use of metallic foams could be a solution to improve mechanical resistance and promote osseointegration of large porous metal devices.Titanium cylinders have been prepared by additive manufacturing(3D printing/rapid prototyping)with a geometric or trabecular microarchitecture.They were implanted in the femoral condyles of aged ewes;the animals were left in stabling for 90 and 270 days.A double calcein labeling was done before sacrifice;bones were analyzed by histomorphometry.Neither bone volume,bone/titanium interface nor mineralization rate were influenced by the cylinder’s microarchitecture;the morphometric parameters did not significantly increase over time.Bone anchoring occurred on the margins of the cylinders and some trabeculae extended in the core of the cylinders but the amount of bone inside the cylinders remained low.The rigid titanium cylinders preserved bone cells from strains in the core of the cylinders.Additive manufacturing is an interesting tool to prepare 3D metallic scaffolds,but microarchitecture does not seem as crucial as expected and anchoring seems limited to the first millimeters of the graft.

关 键 词：TITANIUM trabecular scaffold OSSEOINTEGRATION geometric architecture HISTOMORPHOMETRY 

分 类 号：R318[医药卫生—生物医学工程]