Bioactive sesquineolignans from the twigs of Litsea cubeba  

作　　者：XIA Huan XIA Gui-Yang WANG Ling-Yan WANG Min WANG Ya-Nan LIN Peng-Cheng LIN Sheng 

机构地区：[1]Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China [2]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China [3]College of Pharmaceutical Sciences,Qinghai University for Nationalities,Xining 810000,China

出　　处：《Chinese Journal of Natural Medicines》2021年第10期796-800,共5页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81903489 and 81522050);the Science and Technology Program of Qinghai(No.2018-ZJ-739);the Innovation Platform for the Development and Construction of Special Project of Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province(No.2017-ZJ-Y19);the Fundamental Research Funds for the Central Universities(No.3332019080).

摘　　要：In a continuing search for biological natural products with structure diversity from traditional Chinese herbs,five new sesquineolignans(1−5)were isolated from an ethyl acetate extract of the twigs of Litsea cubeba.Their structures were elucidated based on MS,1D and 2D NMR spectroscopic data,as well as experimental electronic circular dichroism(ECD)spectra.Compounds 1−5 showed moderate inhibitory effects against LPS-induced NO production in RAW264.7 macrophages,with IC50 values of 16.2,20.2,22.1,15.1,and 16.6μmol·L^(−1),respectively.

关 键 词：Litsea cubeba Sesquineolignans NO production inhibitory activity 

分 类 号：R284[医药卫生—中药学]