苦参碱和氧化苦参碱对霉菌性和滴虫性阴道炎临床药理作用的研究进展  

Research Progress in Clinical Pharmacological Effects of Matrine and Oxymatrine in Mycotic and trichomonas Vaginitis

作　　者：张明发[1] 沈雅琴[1] ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《抗感染药学》2021年第8期1083-1087,共5页Anti-infection Pharmacy

摘　　要：苦参碱和氧化苦参碱均具有广泛的生物活性,如保护心、肝、肺、肾、脑、血管的作用,其对心脏有正性肌力、负性频率、抗心律失常的作用,还具有升高白细胞、平喘、抗溃疡、抗纤维化及镇静、催眠、镇痛等中枢神经药理作用,以及抗肿瘤、免疫调节、抗菌、抗病毒、抗寄生虫、抗炎等药理作用;在妇科治疗领域,苦参碱和氧化苦参碱具有抗妇科肿瘤的作用,能保护乳腺上皮细胞、子宫内膜上皮细胞和阴道上皮细胞,也能对抗各种致病因子引起的上皮细胞炎性病变。临床上已被用于治疗各种宫颈炎、阴道炎,也被试用于乳腺癌、卵巢癌、宫颈癌和子宫内膜癌的治疗。本文中综述了苦参碱和氧化苦参碱对霉菌性和滴虫性阴道炎临床治疗的药理作用文献,并对其研究进展做了分析。Matrine and oxymatrine have a widespread bioactivities,including protection of organs(heart,liver,lung,kidney,brain and blood vessel),positive inotropic action,negative chronotropic action, antiarrhythmia,the effect of increasing leukocyte, antiasthma,antiulcer,anti-fibrogenesis,the central nervous pharmacological action(sedation, hypnogenesis and analgesia),antitumor,immunoregulation,anti-bacteria,anti-virus,anti-parasite and anti-inflammation. In gynecologic domain, matrine and oxymatrine have the effects of anit-gynecologic tumors,and could protect epithelial cells of mamma,endometrium and vagina,and antagonize inflammatory pathologic change of epithelial cells induced by various pathogenic factors. Clinically,they have been used in the treatment of various cervicitis and vaginitis,and have also been tried in the treatment of breast,ovarian,cervical and endometrial cancer. In this paper,the pharmacological effects of matrine and oxymatrine in clinical treatment of mycotic and trichomonas vaginitis have been reviewed,and their research progress have been analyzed.

关 键 词：苦参碱 氧化苦参碱 上皮细胞 阴道炎 

分 类 号：R961[医药卫生—药理学]