某院内科门诊克拉霉素处方点评及其潜在药物相互作用分析  

Analysis of Clarithromycin Prescriptions Comments and Potential Drug Interactions in Out-patient Internal Medicine of a Hospital

作　　者：郑晓君 张桂芬[1,2] 王建 ZHENG Xiao-jun;ZHANG Gui-fen;WANG Jian(Department of Pharmacy,Changshu No.1 People's Hospital,Changshu Jiangsu 215500,China;Changshu Hospital Affiliated to Soochow University,Changshu Jiangsu 215500,China)

机构地区：[1]常熟市第一人民医院,江苏常熟215500 [2]苏州大学附属常熟医院,江苏常熟215500

出　　处：《抗感染药学》2021年第8期1093-1097,共5页Anti-infection Pharmacy

摘　　要：目的:分析医院门诊内科克拉霉素处方用药的合理性和药物联合使用情况,为临床合理用药提供参考。方法:通过医院信息系统(HIS),调取2020年10月—12月门诊内科含克拉霉素处方871张,分析其用药的合理性及不合理用药的原因。结果:871张含克拉霉素处方中,处方用药对象主要为30~60岁年龄段人群;以消化内科和普通内科患者为主,处方诊断项主要是幽门螺旋杆菌感染;不合理处方原因主要为"抗菌药物使用欠合理""临床诊断书写不全";与质子泵抑制剂联用处方占87.14%,具有潜在的药物相互作用的联合用药处方较为普遍。结论:医院门诊内科患者,克拉霉素使用存在不合理用药现象,行政部门应加强对临床抗菌药物合理使用和联合用药的管理,提高临床对可能存在潜在药物相互作用的认识和药师的审方能力,以促进临床克拉霉素用药的合理性和安全性。Objective: To analyze the rationality of clarithromycin prescriptions and drug combination in out-patient department, and to provide reference for rational drug use in clinic. Methods: Using the hospital information system(HIS), 871 prescriptions containing clarithromycin were collected from the out-patient internal medicine department from October to December 2020 to analyze the rationality of drug usage and the reasons for irrational drug use.Results: In 871 prescriptions containing clarithromycin, the patients were mainly in the age group of 30 to 60 years old.Most of the patients were in gastroenterology department and general internal medicine department, and the main prescription diagnosis item was Helicobacter pylori infection. Reasons for unreasonable prescriptions were mainly "unreasonable use of antibacterials" and "incomplete writing of clinical diagnosis". The prescriptions combined with proton pump inhibitors accounted for 87.14%, and the prescriptions with potential drug interactions were more common. Conclusion: In hospital out-patient medical patients, the clarithromycin unreasonable drug usage exists, administrative departments should strengthen the clinical rational usage of antibacterial agents and the combination of management, improve clinical awareness of possible drug interaction potential, and to improve pharmacists’ ability to check prescriptions so as to promote the rationality of clarithromycin clinical medication and safety.

关 键 词：门诊内科 克拉霉素 不合理用药 潜在药物相互作用 

分 类 号：R969.3[医药卫生—药理学]