慢性肾脏病血管钙化研究进展  

Updates on vascular calcification in chronic kidney disease

作　　者：杨星梦 马晓迎[1] 生玉平 徐海平[1] 张浩然[1] 王娜[1] 孙福云[1] YANG Xing-meng;MA Xiao-ying;SHENG Yu-ping;XU Hai-ping;ZHANG Hao-ran;WANG Na;SUN Fu-yun(The Second Department of Nephrology,Cang zhou Central Hospital,Hebei Province,Cangzhou 061000,China)

机构地区：[1]河北省沧州市中心医院肾内二科,河北沧州061000

出　　处：《中国当代医药》2021年第31期33-36,共4页China Modern Medicine

基　　金：河北省沧州市重点研发计划指导项目(204106081)。

摘　　要：心血管疾病(CVD)是导致慢性肾脏病(CKD)患者死亡的最常见原因。血管钙化可以造成患者的CVD患病率升高,CKD患者的血管钙化是一种由矿物质代谢异常、激素水平改变、细胞信号通路异常激活、表观遗传学调控等引起的复杂的生理过程。本文综述了CKD患者血管钙化的特点、机制、影响因素等方面的研究进展。Cardiovascular disease(CVD)is the most commom factor for death in patients with chronic kidney disease(CKD).Vascular calcification could promote the morbidty of CVD.Vascular calcification of patients with CKD is a complex biological process which is mediated by the dysregulated form of matrix mineral metabolism,change of hormones,epigenetic regulation and the activation of cellular signaling pathways.This paper reviewed the characteristics,physiological mechanism,influence factors of vascular calcificationin in patients with CKD.

关 键 词：慢性肾脏病 血管钙化 发病机制 心血管疾病 

分 类 号：R692[医药卫生—泌尿科学]