七叶皂苷钠片治疗突发性耳聋患者疗效分析  

Clinical Effect Analysis of Sodium Aescinate Tablet in the Treatment of Patients with Sudden Deafness

作　　者：王伟[1] 强化龙[1] 詹晓东[1] 程忠强[1] 李士强 蒋震枫 丁曌冉 WANG Wei;QIANG Hualong;ZHAN Xiaodong(Department of Otolaryngology,the First Affiliated Hospital of Bengbu Medical College)

机构地区：[1]蚌埠医学院第一附属医院耳鼻咽喉头颈外科,233003

出　　处：《长治医学院学报》2021年第5期345-348,共4页Journal of Changzhi Medical College

基　　金：安徽省高等学校省级质量工程项目(2019jyxm1046)。

摘　　要：目的:探讨七叶皂苷钠片在突发性耳聋患者中的临床治疗效果。方法:回顾性分析88例突发性耳聋患者临床资料,根据治疗方案分为观察组与对照组,各44例。采取地塞米松耳后注射的为对照组,采取地塞米松联合七叶皂苷钠片治疗的为观察组。比较2组治疗效果、治疗前后不同频率听力阈值、血液流变学指标水平、不良反应发生率。结果:观察组总有效率(90.91%)高于对照组(72.73%),差异有统计学意义(P<0.05);治疗后2组250 Hz、500 Hz、1000 Hz听力阈值较治疗前降低,且观察组250 Hz[(26.64±7.21)vs(32.01±7.89)dB]、500 Hz[(33.17±5.80)vs(40.26±6.07)dB]、1000 Hz[(29.83±5.33)vs(35.60±6.87)dB)]听力阈值均低于对照组(P<0.05);治疗后全血高切黏度、低切黏度及血浆黏度较治疗前降低,且观察组全血高切黏度[(3.63±1.11)vs(4.56±1.28)mPa·s^(-1)]、低切黏度[(6.15±1.98)vs(8.71±2.13)mPa·s^(-1)]及血浆黏度[(1.05±0.08)vs(1.33±0.15)mPa·s^(-1)]低于对照组(P<0.05);治疗期间2组均未发生药物相关不良反应。结论:常规干预基础上采用七叶皂苷钠片治疗突发性耳聋,可有效改善患者听力阈值,调节血液流变学状态,提高疾病整体治疗效果。Objective:To investigate the clinical effect of sodium aescinate tablet in the treatment of patients with sudden deafness.Methods:A total of 88 patients with sudden deafness were selected and divided into study group and control group according to simple random number table method,44 cases in each group.The control group was injected with dexamethasone after ear,and the research group was injected with sodium aescinate tablet on the basis of control group.The treatment effect,hearing threshold of different frequencies before and after treatment,hemorheology index level and the incidence of adverse reactions in the two groups were compared.Results:The total effective rate of study group(90.91%)was higher than that of control group(72.73%)(P<0.05).After treatment,the hearing thresholds of 250,500 and 1000 Hz in the two groups were lower than those before treatment,and the hearing thresholds of 250,500 and 1000 Hz in the study group were lower than those before treatment was lower than that in the control group(P<0.05).After treatment,the whole blood high shear viscosity,low shear viscosity and plasma viscosity were lower than those before treatment,and the whole blood high shear viscosity,low shear viscosity and plasma viscosity of the study group was lower than that of the control group(P<0.05).No drug-related adverse reactions occurred in the two groups during the treatment.Conclusion:Based on conventional intervention,sodium aescine tablets for the treatment of sudden deafness can effectively improve the hearing threshold of patients,regulate the state of hemorheology,improve the overall treatment effect of the disease,and the safety is guaranteed.

关 键 词：七叶皂苷钠片 突发性耳聋 听力阈值 血液流变学 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]