腰大池置管连续给药在结核性脑膜炎患者中的实施意义  

Significance of continuous administration via lumbar cistern catheterization in patients with tuberculous meningitis

作　　者：安亮 AN Liang(Department One of Respiration,Yingkou Third People’s Hospital,Yingkou 115003,China)

机构地区：[1]营口市第三人民医院呼吸一科,115003

出　　处：《中国现代药物应用》2021年第18期26-28,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探究腰大池置管连续给药在结核性脑膜炎患者中的应用价值。方法68例结核性脑膜炎患者,按照住院号的单双数分为对照组(单数住院号)及试验组(双数住院号),每组34例。对照组行常规治疗,试验组在对照组的基础上行腰大池置管连续给药。比较两组患者的治疗效果及死亡率,治疗前后的脑脊液指标,症状改善时间,住院时间。结果试验组患者的治疗有效率94.12%高于对照组的73.53%,差异具有统计学意义(P<0.05);两组患者的死亡率比较,差异无统计学意义(P>0.05)。治疗后,试验组患者脑脊液的压力、白细胞计数、腺苷脱氨酶水平均低于对照组,糖、氯化物水平高于对照组,差异具有统计学意义(P<0.05)。试验组患者的发热、癫痫发作、头痛、意识障碍、呕吐改善时间均短于对照组,差异具有统计学意义(P<0.05)。试验组患者的住院时间(17.59±2.17)d短于对照组的(25.12±3.58)d,差异具有统计学意义(t=10.488,P=0.000<0.05)。结论腰大池置管连续给药治疗结核性脑膜炎具有实施价值。Objective To investigate the practical value of continuous administration via lumbar cistern catheterization in patients with tuberculous meningitis.Methods A total of 68 patients with tuberculous meningitis were divided into control group(odd number)and experimental group(even number)according to the odd and even numbers of hospitalization numbers,with 34 cases in each group.The control group was treated with conventional therapy,and the experimental group was treated with continuous administration via lumbar cistern catheterization based on the control group.The therapeutic effect,death rate,cerebrospinal fluid indicators before and after treatment,time to symptom improvement,and hospitalization time were compared between the two groups.Results The effective rate of the experimental group was 94.12%,which was higher than 73.53%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in death rate between the two groups(P>0.05).After treatment,the pressure,white blood cell count,adenosine deaminase levels in the cerebrospinal fluid of the experimental group were lower than those of the control group,and the chloride and blood glucose level were higher than those of the control group.All the difference was statistically significant(P<0.05).The improvement time of fever,seizure,headache,disturbance of consciousness,and vomiting in the experimental group was shorter than those in the control group,and the difference was statistically significant(P<0.05).The hospitalization time of the experimental group was(17.59±2.17)d,which was shorter than(25.12±3.58)d of the control group,and the difference was statistically significant(t=10.488,P=0.000<0.05).Conclusion Continuous administration lumbar cistern catheterization has practical value in the treatment of tuberculous meningitis.

关 键 词：腰大池置管 连续给药 结核性脑膜炎 

分 类 号：R529.3[医药卫生—内科学]