涂阳肺结核患者运用利福喷丁和利福平治疗的效果与安全性分析  

Analysis of the efficacy and safety of rifapentine and rifampin in smear-positive pulmonary tuberculosis patients

作　　者：田越 李辉 李红 TIAN Yue;LI Hui;LI Hong(Tuberculosis Department,Anshan Tuberculosis Hospital,Anshan 114000,China)

机构地区：[1]辽宁省鞍山市结核病医院结核内科,114000

出　　处：《中国现代药物应用》2021年第18期118-121,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析涂阳肺结核患者使用利福喷丁(RIF)与利福平(RMP)治疗的效果与安全性。方法89例涂阳肺结核患者,以抽签法分为A组(45例)与B组(44例)。A组予以LHZE(RIF+异烟肼+吡嗪酰胺+乙胺丁醇)治疗;B组予以RHZE(RMP+异烟肼+吡嗪酰胺+乙胺丁醇)治疗。比较两组病灶吸收效果、空洞闭合率、症状消退时间、不良反应发生率。结果A组的病灶吸收总有效率为97.78%,高于B组的84.09%,差异有统计学意义(P<0.05)。A组的空洞闭合率为93.33%,高于B组的75.00%,差异有统计学意义(P<0.05)。A组咳嗽消退时间(3.28±0.65)d、喘息消退时间(3.33±0.95)d、肺啰音消退时间(5.67±0.64)d短于B组的(5.24±0.81)、(5.98±1.05)、(6.99±0.81)d,差异有统计学意义(P<0.05)。A组不良反应发生率为4.44%,低于B组的18.18%,差异有统计学意义(P<0.05)。结论涂阳肺结核患者进行RIF治疗的效果显著优于RMP,可促进症状消退,且安全效益好。Objective To analyze the effect and safety of rifapentine(RIF)and rifampin(RMP)in smear-positive pulmonary tuberculosis patients.Methods A total of 89 patients with smear-positive pulmonary tuberculosis were divided into group A(45 cases)and group B(44 cases)according to lottery method.Group A was treated with LHZE(RIF+isoniazid+pyrazinamide+Ethambutol),and group B was treated with RHZE(RMP+isoniazid+pyrazinamide+Ethambutol).The effect of lesion absorption,cavity closure rate,symptom resolution time,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of lesion absorption of group A was 97.78%,which was higher than 84.09%of group B,and the difference was statistically significant(P<0.05).The cavity closure rate in group A was 93.33%,which was higher than 75.00%in group B,and the difference was statistically significant(P<0.05).The cough resolution time(3.28±0.65)d,wheeze resolution time(3.33±0.95)d,and lung rale resolution time(5.67±0.64)d in group A were shorter than(5.24±0.81),(5.98±1.05)and(6.99±0.81)d of group B,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in group A was 4.44%,which was lower than 18.18%in group B,and the difference was statistically significant(P<0.05).Conclusion Rif is more effective than RMP in treating smearpositive pulmonary tuberculosis patients.Rif can promote the resolution of symptoms and has good safety.

关 键 词：涂阳肺结核 利福喷丁 利福平 不良反应 

分 类 号：R521[医药卫生—内科学]